نتایج جستجو برای: il 1ß
تعداد نتایج: 139923 فیلتر نتایج به سال:
Introduction: Anabolic activity is a crucial activity in articular chondrocytes and its failure is one major reason of osteoarthritic cartilage degeneration. Unclear are the intracellular factors responsible for upand down regulation of the molecules of interest. In this respect, the transcription factor Sox-9, a member of the HMG-domain transcription factor family, elicited much of interest as...
Background/aim: Renal ischemia-reperfusion (IR) related acute kidney injury (AKI) is an important health problem and has not yet been fully treated. Tarantula cubensis extract (TCE) a homeopathic drug that antiinflammatory antioxidant effects. This study aimed to investigate the effects of TCE on renal in rats. Materials methods: was carried out 48 Spraque-Dawley male rats, which were divided i...
Background Increased neovascularization in the inflamed synovium of patients with rheumatoid arthritis (RA) is a pathological feature pathogenesis RA. Key players RA progression are chronically activated synovial fibroblasts (RASF), which secrete proinflammatory factors (e.g. IL-6), proangiogenic VEGF, IL-11 and matrix metalloproteases (MMP) promoting inflammation, angiogenesis, invasion cartil...
Osteoarthritis (OA) is a common disease in the elderly due to an imbalance in cartilage degradation and synthesis. Heterotopic ossification (HO) occurs when ectopic masses of endochondral bone form within the soft tissues around the joints and is triggered by inflammation of the soft tissues. Procyanidin B3 (B3) is a procyanidin dimer that is widely studied due to its high abundance in the huma...
We aimed to evaluate the effects of ionizing radiation on the proliferation of gingival fibroblasts and the expressions of proinflammatory cytokines and matrix metalloproteinase-1 (MMP-1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and type I collagen (type I Col) mRNA transcripts. Gingival fibroblasts were treated with radiation doses as follows; 0.5 Gy, 1 Gy, 2 Gy, 4 Gy, 6 Gy, an...
Both inflammatory and anti-inflammatory cytokines have been reported to be associated with acute graft-versushost disease (aGVHD). However, their role and possible mutual interactions during aGVHD are not well understood. Eight patients with aGVHD and eight without who had undergone allogeneic HLA-identical peripheral blood stem cell transplantation were studied. The patients had no other compl...
Lipin-1 deficiency is associated with massive rhabdomyolysis episodes in humans, precipitated by febrile illnesses. Despite well-known roles of lipin-1 in lipid biosynthesis and transcriptional regulation, the pathogenic mechanisms leading to rhabdomyolysis remain unknown. Here we show that primary myoblasts from lipin-1-deficient patients exhibit a dramatic decrease in LPIN1 expression and pho...
New chemopreventive alternatives are needed due to the rising worldwide incidence of colorectal cancer. The objective was evaluate activity Moringa oleifera leaves (MO) in a colitis-associated colon carcinogenesis model. We hypothesized that MO contain bioactive compounds capable modulating expression genes involved inflammatory response and carcinogenesis. Forty-eight male mice (CD-1) were div...
Abstract Background Patients with IBD have an altered microbiome and gut microenvironment leading to changes in their Short-Chain Fatty Acid (SCFA) profile. Pathobionts are commensal organisms that become pathogenic under specific conditions, likely related microenvironmental changes. This is especially relevant children given early life exposures critical development impact immune response. Pu...
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