Interleukin (IL)-31 is a key cytokine that contributes to pruritus in atopic dermatitis (AD). Recently, the treatment with anti-IL-31 receptor alpha (RA) antibody exhibited remarkable antipruritic effect AD patients. In clinical trial, serum levels of thymus activation-regulated chemokine (TARC), biomarker AD, were unexpectedly increased some patients treated anti-IL-31RA antibodies, without an...

Dystrophic epidermolysis bullosa pruriginosa (DEB-P) is an extremely itchy variant of DEB. The cause for the itch unknown and there are no effective treatments. We hypothesised a role IgE in DEB-P itch. To explore this, we measured total blood skin 15 non-atopic subjects, two matched control groups non-itchy DEB subjects (DEB-NP) healthy volunteers (HV), via ImmunoCAPTM Total tissue immunofluor...

background: il-17/il-23 axis plays an important role in the pathogenesis of several autoimmune diseases such as experimental autoimmune encephalomyelitis (eae) and multiple sclerosis (ms). the immunomodulatory properties of ginger are reported in previous studies. objective: to evaluate the effects of ginger extract on the expression of il-17 and il-23 in a model of eae. methods: eae was induce...

We have performed pulse-chase experiments to investigate the secretion and processing of interleukin 1 (IL-1) by human peripheral blood monocytes. Polyclonal antisera generated against either recombinant IL-1 alpha (p15) or IL-1 beta (p17) could distinguish the two isoelectric forms in lysates and supernatants of lipopolysaccharide-activated monocytes. In agreement with previous results, no pro...

The aim of this study was to examine the interleukin-1B (IL-1B) gene promoter region -31 (IL-1B-31) polymorphism distribution characteristic of Hakka gastric cancer patients in Guangdong Province and to explore its association with gastric cancer. We used the 1:1 case-control method, matrix-assisted laser desorption ionization flight time mass spectrometry, and MassARRAY-IPLEX technology to gen...

BACKGROUND Pruritus is one of the major features of lichen planus (LP); however, its pathogenesis remains largely unknown. Objective. The aim of our study was to analyze the role of IL-31 in the pathogenesis of pruritus in LP. MATERIALS AND METHODS The study group included 22 patients with LP. Control group consisted of 14 healthy volunteers. All subjects underwent thorough examination. Pruri...

Eccrine sweat is secreted onto the skin's surface and is not harmful to normal skin, but can exacerbate eczematous lesions in atopic dermatitis. Although eccrine sweat contains a number of minerals, proteins, and proteolytic enzymes, how it causes skin inflammation is not clear. We hypothesized that it stimulates keratinocytes directly, as a danger signal. Eccrine sweat was collected from the a...