T HE pathogenetic mechanisms of the excessive hemolysis that occurs in both familial and acquired cases of hemolytic anemia continue to be the subject of much discussion and investigation. Several theories have been advanced to explain these processes, in which spherocytosis of the red cells commonly occurs. In 1938, Dameshek and Schwartz’ first demonstrated that the spherocyte was not necessar...

We describe the first case of cefotetan-induced immune hemolytic anemia (IHA) following sacrocolpopexy. A 65-year-old female status post uncomplicated sacrocolpopexy presented on postoperative day 15 for worsening fatigue. Her exam was notable jaundice and icteric sclerae. Hemoglobin hematocrit were 5.5 g/dL 17.2%, respectively direct anti-globin test positive.

The pathogenesis of vitiligo has been proposed as a destruction of melanocytes by autoimmune processes. Evans syndrome is the combination of autoimmune hemolytic anemia and immune-mediated thrombocytopenia. The antiphospholipid syndrome is characterized by arterial/venous thrombosis, recurrent pregnancy loss, or thrombocytopenia in the presence of antiphospholipid antibodies. We present a case ...

Autoimmune manifestations are increasingly being recognized as a component of several forms of primary immunodeficiencies (PID). Defects in purging of self-reactive T and B cells, impaired Fas-mediated apoptosis, abnormalities in development and/or function of regulatory T cells, and persistence of immune activation as a result of inability to clear infections have been shown to account for thi...

background: sodium bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood ph in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (g6pd) deficiency. the aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematolog...

introduction autoimmune haemolytic anemia (aiha) is a complex process characterized by an immune reaction against red blood cell self-antigens. the analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. this paper was written to alert technologists and pathologists to the presence of cold agglutinins and its ef...