نتایج جستجو برای: immune suppressors

تعداد نتایج: 270947  

Journal: :Genetics 1998
B Patterson

We are using intragenic suppression to generate inferences about currently inaccessible conformations of the molecular motor myosin. We identified 19 unique suppressors of Dictyostelium G680A and G680V mutants and find that they are structurally and chemically restricted, suggestive of specific, compensatory mechanisms of action. Suppressors cluster in two adjacent elements of the myosin struct...

Journal: :Genetics 1980
S W Liebman M Cavenagh

Six partially dominant antisuppressors were obtained that reduce the efficiency of two omnipotent yeast suppressors, sup45 and sup35, thought to be ribosomal ambiguity mutations. Each of these six antisuppressors was shown to fall within a single Mendelian locus, named asu9. The asu9 mutations are specific for omnipotent suppressors; they have no effect on several dominant tRNA-like suppressors...

Journal: :Genetics 1982
M R Culbertson R F Gaber C M Cummins

Two classes of frameshift suppressors distributed at 22 different loci were identified in previous studies in the yeast Saccharomyces cerevisiae. These suppressors exhibited allele-specific suppression of +1 G:C insertion mutations in either glycine or proline codons, designated as group II and group III frameshift mutations, respectively. Genes corresponding to representative suppressors of ea...

Journal: :Journal of the Royal Society, Interface 2012
Marian A C Groenenboom Paulien Hogeweg

Virus infection in plants is limited by RNA silencing. In turn, viruses can counter RNA silencing with silencing suppressors. Viral suppressors of RNA silencing have been shown to play a role in symptom development in plants. We here study four different strategies employed by silencing suppressors: small interfering RNA (siRNA) binding, double-strand RNA (dsRNA) binding and degrading or inacti...

Journal: :FEBS letters 2005
Feng Qu T Jack Morris

RNA silencing as a robust host defense mechanism against plant viruses is generally countered by virus-encoded silencing suppressors. This strategy is now increasingly recognized to be used by animal viruses as well. We present here an overview of the common features shared by some of the better studied plant viral silencing suppressors. We then briefly describe the characteristics of the few r...

Journal: :Plant physiology 2007
Herman B Scholthof

This Update reviews how virus-encoded suppressors of RNA silencing are currently being used in certain areas of plant research and biotechnology. Keeping within the scope of this special Focus issue, an emphasis is placed on the use of gene vectors for expression of suppressors in plants. Toward the end of this review, a discussion is presented on how the choice of vector system may influence t...

Journal: :Journal of bacteriology 1985
J M Song S W Liebman

Haploids bearing the dominant UAG suppressor, SUP7-a, and various alleles of the omnipotent suppressor sup35 were examined. The presence of the UAG suppressor reduced the efficiency of some alleles of sup35, and caused other sup35 alleles to be lethal. A nonclassical interaction of the dominant suppressor tRNA and the ribosome is proposed to explain these observations.

Journal: : 2021

Objective — to investigate immuno-metabolic homeostasis in patients with new and recurrent cases of destructive forms multidrug-resistant pulmonary tuberculosis (MDR-PTB) after treatment bedaquiline linezolid. Materials methods. A clinical laboratory examination 175 people MDR-PTB (89 86 MDR-PTB). The study was performed before total leukocytes count (L), the leukocyte differential (leukocyte f...

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