Because of the rareness reports about immune thrombocytopenic purpura patients undergoing cardiac surgery, there is no sufficient knowledge perioperative strategies. In this article, we report a 42-year-old female patient with severe mitral regurgitation and large right atrial thrombus, in whom thrombocytopenia had disappeared after valve replacement thrombectomy from atrium. Large thrombi shou...

Background: Splenic infarction (SI) is a rare clinical entity seldom encountered in veterinary medicine. Its most frequent causes include thromboembolic status, splenomegaly, and cardiac disease. Although thrombotic elements from the circulation provide the most common context for thromboembolic SIs, immune-mediated hemolytic anemia (IMHA) has not been reported as an underlying...

Thrombocytopenia is a common condition in distressed newborns, but little is known about thrombocytopenia in an unselected cohort of neonates. In an attempt to address this issue, a multicenter prospective study was conducted in three obstetrical wards of AP-HP in Paris. We found the frequency of neonatal thrombocytopenia (<150 x 10(9)/L) to approximate 0.9% (48 of 5,632 appropriate samples). A...

Background Checkpoint blocking agents such as pembrolizumab or nivolumab may induce a diversity of mostly autoimmune-mediated side effects. These autoimmune phenomena mainly affect ductless glands such as the pituitary gland (hypophysitis), the thyroid gland (thyreoiditis), the skin (vitiligo and rash), the colon (colitis), and the lung (pneumonitis). Furthermore, many other organs or organ sys...

Abstract There are several vaccines developed against COVID-19 infection. Inactivated viral usually well tolerated. We aimed to present a relapsing immune thrombocytopenia case following inactive vaccine. Here we report of inactivated vaccine in 60-year-old woman with history thrombocytopenia. The patient responded dexamethasone treatment and was discharged from the hospital full recovery. sugg...

Hereditary thrombocytopenias are rare bleeding disorders, which cause a deficiency of platelets in early infancy. This group of disorders is sometimes associated with abnormal phenotypes, like absence of radius. Diagnosis of this type of thrombocytopenia is usually difficult; other causes of thrombocytopenia, such as immune disorders and infections, must be ruled out. The symptoms of hereditary...

Two teams of researchers have published detailed observations patients who developed thrombotic thrombocytopenia after receiving the AstraZeneca vaccine and speculated about a possible mechanism.12 Both groups suggest that development serious blood clots alongside falling levels platelets is an immune response resembles rare reaction to drug heparin, called heparin induced thrombocytopenia. Th...

immunodeficiency and autoimmune disease may occur concomitantly in the same individual. some of the immunodeficiency syndromes, especially humoral defects are associated with autoimmune disorders. hematological manifestations such as thrombocytopenia and hemolytic anemia are the most common presentations. persistent antigen stimulation due to an inherent defect in the ability of the immune syst...