The results of experiments reported by a number of investigators have led to the conclusion that the reactions of the host against tumor grafts are due to an immunity which develops against the transplanted tissues, and that this immunity is specific for the tumor. Thus DaFano (8) noticed in mice that after the transplantation of a piece of carcinoma of the mammary gland, lymphocytes and monocy...

Host immunity to a growing antigenic solid tumor was studied with a transplanted methylcholanthrene-induced sarcoma (MCA-25) in inbred female strain 2 guinea pigs. Tumor-specific cellular immunity was evaluated in vivo by delayed cutaneous hypersensitivity reactions to a transplanta tion antigen extract of the tumor and in vitro by splenic lymphocyte-mediated cytoxicity. Animals receiving 100,0...

Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native type II collagen. Furthermore, electron-dense deposits were seen near the surface of chondrocytes...

Recent studies have radically changed our views of the development of acquired immunity during gestation and perinatal life. It is now apparent that there are considerable differences in the way the immune response matures in different species (Sterzl and Silverstein, 1967; Adinolfi and Wood, 1969; Solomon, 1971). In mice and rats immune reactions are relatively immature even in the newborn. In...

Children with kwashiorkor showed a high incidence of deranged cellular immunity as evidenced by impairment of delayed cutaneous hypersensitivity reactions to candida and diphtheria toxoid antigens and of lymphocyte transformation after phytohaemagglutinin stimulation. This may contribute to their susceptibility to infection. A correlation was shown between the degree of impairment of tests of c...

Lymphocytes which undergo maturation in the thymus are essential for cellular immunity and for the antibody response to some antigens. In the mouse it has been shown that thymus-derived (T) 1 lymphocytes are required for rejection of skin allografts (1, 2), initiation of graft-versus-host (GVH) reactions (2), development of killer cells specific for histoincompatible tumor cells (3), developmen...

Dendritic cells (DC) are highly specialized antigen-presenting cells (APC) that are pivotal in regulating the balance between immune tolerance and protective immunity. This functional versatility is highlighted in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT), where DC are crucial for the induction and modulation of graft-versus-host reactions. Furthermore, in th...

plunges in medias res, and in terse and lucid language deals in succession with the body fluids, the cell, and the micro-organism as factors in immunity, and then with immunity-reactions employed for therapeutic ends and for diagnostic purposes, ending with a chapter on anaphylaxis. The kindred topics of salvarsan and neo-salvarsan are briefly treated in an appendix. To what extent the writer d...

Recent studies have radically changed our views of the development of acquired immunity during gestation and perinatal life. It is now apparent that there are considerable differences in the way the immune response matures in different species (Sterzl and Silverstein, 1967; Adinolfi and Wood, 1969; Solomon, 1971). In mice and rats immune reactions are relatively immature even in the newborn. In...

Abstract Eusocial insects can employ various behavioural and physiological disease defences to avoid, resist tolerate pathogen infections in their closely related packed colonies, termed social immunity. Recent studies have shown that several molecules serve insect immunity, including chemical odours, venoms, immune-related proteins, etc. However, whether how microRNAs (miRNAs), whose precursor...