BACKGROUND Facial composite tissue allotransplantation is a potential reconstructive option for severe facial disfigurement. The purpose of the present investigation was to use decision analysis modelling to ascertain the expected quality-adjusted life years (QALYs) gained with face transplantation (versus remaining in a disfigured state) in an effort to assist surgeons with the decision of whe...

BACKGROUND Although the biological basis for the increased susceptibility of diabetic patients to tuberculosis remains unclear, the world is undergoing a type 2 diabetes pandemic. We hypothesize that chronic hyperglycemia leads to immunocompromise that facilitates progression to active tuberculosis. To assess this possibility, we determined whether patients with tuberculosis and diabetes (parti...

BACKGROUND We and others have shown that primary hepatitis C (HCV) infection in men infected with human immunodeficiency virus (HIV) causes early-onset liver fibrosis; however, little is known about the long-term natural history of the liver disease in these HIV-infected men. METHODS We followed a cohort of HIV-infected men with primary HCV infection in New York City. RESULTS Four men who w...

950 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 6, June 2007 To our knowledge, detection of Bartonella spp. DNA in sea turtle blood represents the fi rst molecular evidence of Bartonella infection in nonmammalian vertebrates. B. henselae infection, now reported in porpoises and sea turtles, may represent an emerging infection of marine animals. According to previous studies, i...

Pyogenic myositis is a primary subacute deep bacterial infection of the skeletal muscle. It is a rare condition that is usually regarded as a tropical disease being common in parts of Africa and the South Pacific. It has been reported in patients of all ages but is predominantly a condition afflicting children and young adults. The development of pyogenic myositis is thought to arise from a tra...

Background In 2017, the Australian National Cervical Screening Program (NCSP) implemented five-yearly primary human papillomavirus (HPV) screening for women aged 25–74. It is important that clinicians are able to explain NCSP changes and confidently address concerns. Aims This study examined clinicians’ attitudes toward experiences of renewal since its implementation. Materials Methods Cross-se...

BACKGROUND Anticonvulsant hypersensitivity syndrome (AHS) is a serious but poorly understood and little known disease. It has been variously described in the literature since 1934. Fatalities are rare but have been reported. METHODS A MEDLINE search was undertaken from 1991 to present, using the keywords "anticonvulsant," "phenytoin," and "hypersensitivity." English language articles and thei...

BACKGROUND Necrotizing soft tissue infections (NSTIs) are aggressive infections associated with significant morbidity, including amputation and organ failure, and high mortality. The rapid progression and significant risk of morbidity and mortality associated with NSTIs makes quick diagnosis and treatment critical. The objective of this study was to determine the presentation of patients diagno...

To investigate the role of CD3-positive T cells in allogeneic marrow rejection in mice and to examine the effects of anti-CD3 monoclonal antibody (MoAb) on allogeneic marrow engraftment, a hamster MoAb, 145-2C11, with specificity for the CD3 epsilon portion of the murine T-cell receptor complex was administered to B6 (H-2b) mice that had been sublethally irradiated with 626 cGy and injected wit...

INTRODUCTION We aimed to compare intensive care unit mortality due to non-pneumococcal severe community-acquired pneumonia between the periods 2000-2002 and 2008-2014, and the impact of the improvement in antibiotic strategies on outcomes. METHODS This was a matched case-control study enrolling 144 patients with non-pneumococcal severe pneumonia: 72 patients from the 2000-2002 database (CAPUC...