cyclophosphamide (cp) is extensively used as an antineoplastic agent for the treatment of various cancers, as well as an immunosuppressive agent. however, despite its wide spectrum of clinical uses, cp is known to cause several adverse effects including reproductive toxicity. crataegus monogyna is one of the oldest pharmaceutical plants that have been shown to be cytoprotective by scavenging fr...

PURPOSE Limited data are available on immunologic responses to primary pandemic H1N1 (2009) vaccination in recipients of allogeneic hematopoietic stem cell transplantation (HSCT) recipients. In 2009 serologic responses to either pandemic H1N1 (2009) vaccine (n = 36) or pandemic H1N1 (2009) infection (n = 2) were studied in 38 HSCT recipients. METHODS Responses were measured with a standard he...

The effects of the human and bovine LSF (derived from sera) as well as their purified fractions were studied on murine lymphocytes reactions indicated by blast transformation (BT) assay, mixed lymphocyte culture (MLC) and IgG synthesis. The results indicated that bovine lipid suppressor factor (LSF) has significant immunosuppressive activity on lymphocytes proliferation both in BT and MLC ...

Diabetes is associated with high risk for vascular disease, and aggressive lipid management is generally necessary. The management of dyslipidemia in patients with diabetes requires attention to the full lipid profile, since hypertriglyceridemia is particularly common. This study aimed to determine the effect of taurine, selenium and azathioprine on diabetic complications, including plasma gluc...

Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC(50) of 3 μM, suggestive of a physiological r...

Cyclophosphamide significantly diminished the canine humoral antibody response to sheep red blood cells and tended to prevent arterial lesions in renal homografts. However, cyclophosphamide failed to prolong renal homograft survival when administered to dogs as the sole immunosuppressive agent, and it did not add to the effectiveness of azathioprine when given as a supplement to the azathioprin...

A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosu...

Since the advent of the potent immunosuppressive agent FK 506, intestinal transplantation has become a feasible therapeutic option for patients with irreversible intestinal failure. In this chapter, we present our clinical experience with intestinal transplantation, focusing on the technical aspects of both the donor and recipient operations. The logistics of the operative procedure have been d...

Polyclonal anti-thymocyte globulin (ATG) is used as an immunosuppressive agent in the treatment of aplastic anemia (AA). Serum sickness is a recognized side effect of ATG. We observed abnormal skin manifestation in patient with aplastic anemia who had been treated with ATG. We conclude that abnormal immune function caused by aplastic anemia and ATG and corticosteroids may aggravate the signs of...