Chronic lymphocytic leukemia (CLL) is a haematopoetic neoplasm caused primarily by defects in apoptosis mechanisms and complicated by progressive marrow failure, immunosupression and increased resistance to chemotherapy. The CD40-CD40 ligand (CD40L) interaction has been shown to significantly increase antigen presentation in normal and malignant B-cells and it is a powerful regulator of cell su...

BACKGROUND Due to a recent alarming increase in the number of HIV-HCV co-infected patients in Romania. OBJECTIVES A cross sectional study was conducted to assess the baseline predictors of liver disease evolution. PATIENTS AND METHODS 83 HIV-HCV co-infected patients, untreated for HCV infection, were evaluated for viral replication, liver fibrosis (estimated by a noninvasive marker - FIB4),...

SUMMARY The effect of L-asparaginase on imm'unosuppression in mice was studied with procedures measuring the ability to produce circulating antibodies against sheep erythrocytes and allogeneic tumor cells and the'incidence of tumor take in the allogeneic mice. The production of anti-sheep erythocyte antibodies on primary immune response in C57BL/Na X A/Jax F1 mice was markedly suppressed at a d...

BACKGROUND Microsporidia (Fungi) have been repeatedly identified as the cause of opportunistic infections predominantly in immunodeficient individuals such as AIDS patients. However, the global epidemiology of human microsporidiosis is poorly understood and the ability of microsporidia to survive and multiply in immunocompetent hosts remains unsolved. AIMS To determine the presence of latent ...

BACKGROUND Long-term outcomes of antiretroviral therapy (ART) in children remain poorly documented in resource-limited settings. The objective of this study was to assess two-and three-year survival, CD4 evolution and virological response among children on ART in a programmatic setting in Cambodia. METHODS Children treated with first-line ART for at least 24 months were assessed with viral lo...

BACKGROUND Alveolar echinococcosis (AE) is a severe chronic hepatic parasitic disease currently emerging in central and eastern Europe. Untreated AE presents a high mortality (>90%) due to a severe hepatic destruction as a result of parasitic metacestode proliferation which behaves like a malignant tumor. Despite this severe course and outcome of disease, the genetic program that regulates the ...

Recent clinical data have pointed towards a potentially devastating consequence of exposure to anaesthetic agents on cancer recurrence and metastasis [3-7]. During surgery bacterial contamination is inevitable but all the patients do not land up in sepsis. Similarly, inadvertent seeding of tumor cells during surgical procedure eventually leading to clinical metastasis is a complex dynamic proce...

BACKGROUND Tuberculosis remains a serious public health threat and economic burden in Russia with escalating rates of drug resistance against a background of growing HIV-epidemic. Samara Oblast is one of the regions of the Russian Federation where more than 1% of the population is affected by the HIV-epidemic; almost half of the cases are concentrated in the largely-industrial city of Togliatti...

Polychlorinated biphenyls (PCBs 28, 31, 52, 101, 138, 153, 180, and 209) were measured in tissue samples (liver and fat) from 30 loggerhead turtles Caretta caretta, 1 green turtle Chelonia mydas, and 1 leatherback Dermochelys coriacea stranded on the coasts of the Canary Islands, trying to establish a possible relation between PCB concentrations and the lesions and causes of death. Tissues from...

With the aim to promote the elaboration of consensus documents on state of the art topics in liver transplantation with multidisciplinary management, the Spanish Society for Liver Transplantation (SETH) organized the V Consensus Meeting with the participation of experts from all the Spanish liver transplant programs. In this edition, the following topics were revised, and we present the summary...