Background Blood sampling is a usual and painful procedure on preterm infant. Repeating painful procedures may affect the process of normal brain development and Pain management is important for nurses. This study was conducted to evaluate and compare pain score in two sites of blood sampling in preterm infants. Materials and Methods Blood sampling is a usual and painful procedure on preterm in...

the bioavailability of two dipyridamol tablet formulations of (dipyridamole from tolidaru and persantin from boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (t) and the reference (r) products in a randomized balanced 2-way crossover design. plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by hplc ...

a bioequivalence study of two verapamil formulations (generic verapamil tablets and isoptin® tablets) was performed by comparing pharmacokinetic parameters of the parent drug and its major metabolite, norverapamil following a single dose administration of 80 mg verapamil hydrochloride in 22 healthy volunteers according to a randomized, two-period, crossover-design study. moreover, the feasibili...

Familial Hypercholesterolemia To the Editor: Verhaar and colleagues, in their recent article,1 report on improvement in forearm endothelial function after 4 weeks’ oral treatment with folic acid at a dose of 5 mg daily in 20 subjects. They used a randomized crossover design without an intervening washout period. Our research group conducted a similar randomized crossover study of folate supplem...

Alternative designs can increase the feasibility of pediatric trials when compared to classical parallel designs (PaD). In this work we present a model-based approach based on clinical trial simulations for the comparison of PaD with the alternative sequential, crossover, and randomized withdrawal (RWD) designs. Study designs were evaluated in terms of: type I and II errors, sample size per arm...