Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat model using letrozole (LET), a nonsteroidal aromatase inhibitor, mimicked multiple PCOS phenotypes, including metabolic features absent in other models. Given the advantages of using genetic and transgenic mouse models, ...

In patients with normogonadotropic anovulation, either with or without polycystic ovary syndrome (PCOS), factors interfering with FSH action may be involved in arrested follicle development. The aim of this study is to assess whether factors inhibiting FSH receptor activation are elevated in serum or follicular fluid from anovulatory patients, as compared with regularly cycling women. For this ...

difficult diagnosis in endocrinology, gynecology, and reproductive medicine. to help solve this issue, the rotterdam consensus conference proposed to include the ultrasonographic follicle count as a new diagnostic criterion, in addition to hyperandrogenism and oligo-anovulation. unfortunately, its assessment does not offer sufficient reliability worldwide. objective: to explore the possible rol...

background: poly cystic ovarian syndrome (pcos) is the most prevalent endocrinopathy among women and the most common underlying diagnosis for anovulatory infertility. the role of insulin-resistance (ir) and hyperinsulinemia in pathophysiology and clinical manifestations of the syndrome depicts the importance of evaluation of the efficacy of insulin reducing medications. n acetyl cysteine (nac) ...

OBJECTIVE To evaluate hormonal changes and pelvic sonography in polycystic ovary syndrome (PCOS) patients, especially free testosterone and their correlations with skin manifestations of this disease. METHODS This prospective study was carried out in the Skin Clinic, Baghdad Teaching Hospital, Iraq in the period between April 2004-March 2005. We included 126 patients with PCOS in this study. ...

Premature menopause and unexplained infertility are associated with ovarian antibodies, a marker of ovarian autoimmunity. In premature menopause, FSH is also elevated while in unexplained infertility FSH concentrations are often normal. The relationship of ovarian antibodies and FSH and inhibin B, as markers of follicle function, was investigated in unexplained infertility. Ovarian antibodies w...

Objective: To study the changes of age-related serum Follicle Stimulating Hormone (FSH) level and Xray of knee joint and the relationship between FSH and postmenopausal knee osteoarthritis in postmenopausal women. Methods: 248 postmenopausal women aged over 50 y were randomly selected from Shandong Provincial Hospital affiliated with Shandong University after excluding patients with related dis...

BACKGROUND Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies. However, there have been no prospective studies evaluating the incidence of aneuploidies in relation to basal FSH concentrations. Since the majority of aneuploid conceptions end in early pregnancy loss or abortion of a recognized pregnancy, these determinants are appropriate intermed...

In order to throw further light on the role of androgens in the aetiology of the polycystic ovary syndrome (PCO) we have examined the effect of artificially increasing serum testosterone levels on menstrual function in a group of ovulating women. Six women were studied who had either severe premenstrual syndrome or loss of libido for which they were treated with 100 mg testosterone by s.c. impl...