Examination of thermal degradation of natural and synthetic lacquer films by pyrolysis-gas chromatography with mass spectrometry (Py-GC/MS) is reviewed. Due to the instantaneous heating decomposition, side reactions of internal or intermediate samples hardly occur, and the pyrolysis products can be retrieved without any change. Py-GC/MS has been used to analyze the composition of insoluble poly...

The stream cipher TPypy has been designed by Biham and Seberry in January 2007 as the strongest member of the Py-family ciphers, after weaknesses in the other members Py, Pypy, Py6 were discovered. One main contribution of the paper is the detection of related-key weaknesses in the Py-family of ciphers including the strongest member TPypy. Under related keys, we show a distinguishing attack on ...

Pyridine (PY) effects on rat hepatic cytochromes P450 (CYP) 3A1 and 3A2 expression were examined at the levels of metabolic activity, protein, and mRNA and were compared with those of CYP2B1/2 and CYP2E1. CYP3A metabolic activity as well as CYP3A protein and mRNA levels increased following treatment of rats with PY. CYP3A1 and CYP3A2 were differentially affected by PY treatment in terms of indu...

The E3-ubiquitin ligase, c-Cbl, is a multi-functional scaffolding protein that plays a pivotal role in controlling cell phenotype. As part of the ubiquitination and downregulation process, c-Cbl recognizes targets, such as tyrosine kinases and the Sprouty proteins, by binding to a conserved (NX/R)pY(S/T)XXP motif via its uniquely embedded SH2 domain (TKB domain). We previously outlined the mode...

Born 1963; diploma in architecture and in civil engineering; Ph.D. in structural engineering RWTH Aachen; founder of Bureau d’études Weinand, Liège; professor at EPFL and director of the IBOIS/EPFL Lausanne; co-founder of SHEL Architecture Engineering and Production Design, Geneva. Olivier BAVEREL Associate Prof. Dr. Navier Research center, ENPC, Champs-sur-Marne ENSAG, France [email protected]

INTRODUCTION The efficacy and safety of tocilizumab in patients with rheumatoid arthritis have been evaluated in a comprehensive phase 3 program. Patients from these randomized trials could receive tocilizumab treatment in open-label extension trials. Here, the long-term safety profile of tocilizumab, using pooled data from all of these trials, is reported. METHODS Cumulative safety data (as ...

Recently, "superbinder" SH2 domain variants with three amino acid substitutions (sSH2) were reported to have 100-fold or greater affinity for protein-phosphotyrosine (pY) than natural SH2 domains. Here we report a protocol in which His-tagged Src sSH2 efficiently captures pY-peptides from protease-digested HeLa cell total protein extracts. Affinity purification of pY-peptides by this method sho...

Reactions of the lithium salts [{RAl(2-py')3Li·THF] [2-py' = 2-py (2-pyridyl), R = (n)Bu (1), R = (sec)Bu (2); py' = 5-Me-2-py (5-methyl-2-pyridyl), R = Me (3); 6-Me-2-py (6-methyl-2-pyridyl), R = Et (4b)] with the corresponding metal(ii) halides give the new heterobimetallic sandwich compounds [{RAl(2-py)3}2M] [R = (n)Bu, M = Ca (5), Mn (6), Fe (7); R = (sec)Bu, M = Ca (8), Mn (9)], [{MeAl(5-M...