Background: Pain is one of the most common complaints that patients present to emergency department for; medicine providers are tasked with providing appropriate pain relief while simultaneously limiting risk personal and societal harm may result from opioid misuse. The Lakeland Regional Medical Center developed a medical management program identified frequent visitors chief complaint pain. Ind...

Clinical genomics is now a reality and lies at the heart of individualized medicine efforts. The success of these approaches is evidenced by the increasing volume of publications that report causal links between genomic variants and disease. In spite of early success, clinical genomics currently faces significant challenges in establishing the relevance of the majority of variants identified by...

The genomic revolution enabled the clinical inclusion of an immense body of person-specific information to an extent that is revolutionizing medicine and science. The gut microbiome, our "second genome," dynamically integrates signals from the host and its environment, impacting health and risk of disease. Herein, we summarize how individualized characterization of the microbiome composition an...

The development and clinical implementation of evidence-based precision medicine strategies has become a realistic possibility, primarily due to the rapid accumulation large-scale genomics pharmacological data from diverse model systems: patients, cell lines drug perturbation studies. We introduce novel Bayesian modeling framework called individualized theRapeutic index (iRx) integrate high-thr...

The last decade has witnessed dramatic improvements in DNA sequencing technology with reduced cost, increased throughput, and improved analytic tools and resources. A consequence of this technologic revolution is the rapid emergence of approaches applying these next-generation sequencing (NGS) methods to many areas of medicine including discovery research and clinical diagnosis. Some consequenc...

BACKGROUND Acupuncture is an effective yet complex therapy, integrating syndrome differentiation, selection of appropriate acupoints and skillful needling techniques. Clinicians carefully tailor acupuncture treatment to each patient. However, most clinical trials of acupuncture have been based on a standardized formula of points for every patient without properly accounting for individualdiffer...

Sasang constitutional medicine (SCM) is a unique traditional Korean therapeutic alternative form of medicine. Based on the Yin and Yang theory and on Confucianism, humans are classified into four constitutions. These differ in terms of (i) sensitivity to certain groups of herbs and medicines, (ii) equilibrium among internal organic functions, (iii) physical features and (iv) psychological chara...