OBJECTIVE To investigate the effect of altering internal Na and cell Ca load on the voltage-dependence of the intracellular Ca transient. METHODS Ventricular myocytes were isolated enzymatically from the guinea-pig heart. They were patch clamped and dialysed internally with pipette solutions which contained either 0 or 10 or 20 mM Na. Intracellular Ca was monitored with Indo-1 and experiments...

Consumption of fruits plays a special role in prevention and treatment of various diseases. Fruits have several compounds with antioxidant properties. Kiwifruit is one of the most popular fruits worldwide and is cultivated in many countries. It is a rich source of several compounds with antioxidant properties such as polyphenols, flavonoids and vitamins. The aim of this study is to evaluate the...

BACKGROUND Focusing on novel drug combinations that target different pathways especially apoptosis and MAPK could be a rationale for combination therapy in successful treatment of lung cancer. Concurrent use of cyclooxygenase (COX) inhibitors with arsenic trioxide (ATO) might be a possible treatment option. METHODS Cytotoxicity of ATO, dexamethasone (Dex), celecoxib (Cel), and Indomethacin (I...

Plosives in Indo-Aryan languages such as Hindi and Marathi display a 4-way contrast involving the two dimensions of voicing and aspiration. While many studies are available on the acoustics of aspiration in unvoiced stops due to their more universal presence in the world’s languages, voiced aspirated plosives have been less studied. Rather than the release duration cue of aspiration in unvoiced...