This study aimed comparison the gastric ulcer induced by indomethacin, aspirin, and ethanol on level of pathological changes, ulcers surface area, index. Forty rats were divided into 4 groups: control group received normal saline, remaining groups, Indomethacin 40 mg/kg, Aspirin group100 80% 5 ml/kg, all doses orally administrated one time. The result revealed had largest whereas indomethacin a...

Background: Several plants are used as analgesic in traditional medicine. Capparis spinosa (C. spinosa) is widely for the treatment of gout and rheumatic arthritis. The previous studies have reported antinociceptive effects this plant. Objectives: study was aimed at examining C. spinosa’s gastric-ulcerogenecity effect comparison to indomethacin. Methods: percolated extract Indomethacin were ora...

OBJECTIVE The pharmacokinetics of a 100 mg vaginal progesterone suppository was evaluated on days 1 and 7 and a 200 mg suppository on day 14. All the volunteers were given oral 17 beta-estradiol during the study. STUDY DESIGN Ten postmenopausal women volunteered for this study. Progesterone was given as a vaginal suppository. Peripheral venous samples were obtained at appropriate intervals an...

Ph.Eur. and BP have introduced a dissolution apparatus for suppositories. Suitability of the apparatus for quality control of paracetamol suppositories was evaluated and the effect of experimental conditions on dissolution profiles was studied. Paracetamol suppositories containing 80-500 mg of the drug, on fatty base, were obtained from four manufacturers (A, B, C, D). The diffusion cell was mo...

OBJECTIVE To determine reduction in dose of tramadol and side effects in posthysterectomy patients on addition of diclofenac on rectal suppository. STUDY DESIGN Randomized double blinded placebo controlled study. PLACE AND DURATION OF STUDY The Aga Khan University Hospital, Karachi, Pakistan, from August 2004 to January 2006. METHODOLOGY Seventy ASA I and II females, aged 20 and above, wh...

AIMS Miconazole is a synthetic imidazole antifungal that has a broad spectrum of activity against Candida albicans and non-albicans Candida species. The aim of this study was to evaluate the efficacy and safety of miconazole nitrate vaginal suppository and oral fluconazole in treating severe vulvovaginal candidiasis (SVVC). METHODS In this prospective, randomized case control study, 577 cases...

Aim: We assessed the safety and efficacy of three different local anesthesia methods (pudendal nerve blockade, tenoxicam suppository and rectal lidocaine gel) before transrectal ultrasound (TRUS)-guided biopsy of the prostate in this study. Materials and Methods: In our prospective and controlled study, 136 consecutive patients were randomized into four groups: men in group 1 (n=41) received no...

Purpose: Prolong labour contributes to increased perinatal and maternal morbidity. Inhibitory impulses in the form of spasm often impair the dilatation of cervix and prolong the duration of labour. This study was undertaken to compare the effect of intramuscular Valathemate bromide [Epidosin] and Hyoscine N Butylbromide [Buscopan] rectal suppository on duration of labour and rate of cervical di...