1Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 2Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA 3Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA 4Division of Infectious Diseases, Cincinnati Children’s Hospit...

1Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece 2Institute of Technology of Agricultural Products, Hellenic Agricultural Organization-DEMETER, 15310 Athens, Greece 3Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AD, UK 4School of Biomedical Scienc...

Throughout human history, natural products—including terrestrial plants, animal products, marine organisms, and products of microorganismal fermentation—have been used in traditional medicines. This historical experience with natural products as therapeutic agents has evolved to sophisticated isolation of active chemical entities from ethnopharmacological plants with the effect that, in modern ...

Crude extracts from Warburgia ugandensis Sprague, Azadirachta indica, Tagetes minuta and Urtica massaica have been tested against soil pathogens; Fusarium oxysporum, Alternaria passiflorae and Aspergillus niger. The results obtained showed biological activity against these pathogens except for U. massaica extract, which was not active. Separation of the crude extract from W. ugandensis yielded ...

Thrombosis is considered to be closely related to several diseases such as atherosclerosis, ischemic heart disease and stroke, as well as rheumatoid arthritis, hyperuricemia, and various inflammatory conditions. More and more studies have been focused on understanding the mechanism of molecular and cellular basis of thrombus formation as well as preventing thrombosis for the treatment of thromb...

Secondary metabolites (or natural products) are often synthesized by multi-modular, multi-domain proteins called non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS). Various well-known metabolites produced by microorganisms are listed in Table 1, and examples of structures are shown in Fig. 1. In particular, Streptomyces species are known for their ability to produce a wide ...

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Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV), is an immunosuppressive disease that results in life-threatening opportunistic infections and malignancies. Despite continuous advances made in antiretroviral therapy, AIDS has become the leading cause of death in Africa and fourth worldwide; the number of people with HIV is increasing at an alarming rate i...

Researchers in the post-genome era are confronted with the daunting task of assigning structure and function to tens of thousands of encoded proteins. To realize this goal, new technologies are emerging for the analysis of protein function on a global scale, such as activity-based protein profiling (ABPP), which aims to develop active site-directed chemical probes for enzyme analysis in whole p...