In diabetic patients, the corrected QT (QTc) interval is relatively long (1). In accordance with the concept of “reduced repolarization reserve” (2), a subsequent increase in QTc interval by proarrhythmic drugs may lead to cardiac arrhythmias and sudden death. Recently, it was shown that patients with diabetes are at increased risk of drug-induced arrhythmias (3). We developed a decision tool t...

1. The ED50 of acetyl strophanthidin for producing ventricular arrhythmias in normal dogs was 54.5 mug/kg intravenously.2. Doses up to and including those which caused ventricular tachycardia did not produce either atrial arrhythmias or significant aberration of A-V conduction.3. Although the classic digitalis-induced rate and e.c.g. waveform changes may appear after administration of acetyl st...

The incidence of the various types of arrhythmia induced by defibrillation in anesthetized dogs that had had continuous ventricular fibrillation for 30 seconds was studied as a function of the current strength and the duration of the unidirectional rectangular pulse used to terminate the fibrillation. Shocks at 10, 20, 40, 80, and 100 amp with durations in the range of 80 fisec through 64 msec ...

BACKGROUND: Glucose-insulin-potassium (GIK) demonstrates a cardioprotective effect by providing metabolic support and anti-inflammatory action, may be useful in septic myocardial depression. AIM: The aim of this study was to assess role GIK infusion improving hemodynamics patients with shock addition its protection preventing occurrence sepsis-induced dysfunction arrhythmias. METHODS: This cond...

Reperfusion-induced arrhythmias were elicited in the pentobarbitone-anaesthetized rat by occlusion of the left main coronary artery and subsequent release. These arrhythmias were rapid in onset, occurring within 20 s after release of the ligature, and were of short duration (1-2 min). Their severity was dependent upon the duration of the preceding occlusion. A 5 or 15 min occlusion period produ...

The transient receptor potential Melastatin 4 (TRPM4) channel is a calcium-activated non-selective cation expressed widely. In the heart, using knock-out mouse model, TRPM4 has been shown to be involved in multiple processes, including β-adrenergic regulation, cardiac conduction, action duration and hypertrophic adaptations. This was recently stress-induced arrhythmias model overexpressing vent...

introduction: prolongation of qt interval might result in dangerous cardiac arrhythmias, including torsades de pointes (tdp), consequently leading to syncope or death. a limited number of studies carried out in this respect to date have shown that qt interval might increase during pregnancy. on the other hand, it has been shown that each pregnancy might result in an increase in the risk of card...