Although it seems intuitive to address the issue of reduced plantar cutaneous feedback by augmenting it, many approaches have adopted compensatory sensory cues, such as tactile input from another part body, for multiple reasons including easiness and accessibility. The efficacy might be limited due cognitive involvement interpret cues. objective this study is test hypothesis that augmentation m...

OBJECTIVE AND METHODS We have previously demonstrated that mechanical loading of cardiac fibroblasts leads to increased synthesis and gene expression of the extracellular matrix protein collagen. We hypothesised that the upregulation of procollagen gene expression in cardiac fibroblasts, in response to cyclic mechanical load, is mediated by one or more members of the MAP kinase family. To test ...

Serotonin specific reuptake inhibitors (SSRI) may induce antinociception however, the mechanism of this effect is not clear. SSRls increase 5-HT levels in neuronal synapses and facilitate serotonergic activity. In this study, therefore, the activity of para-chlorophenylalanine (pCPA), which reduces 5-HT release, and 5- hydroxy tryptophan (5-HTP), a precursor of 5-HT, were examined on the a...

hydatid disease is a rare parasitic disease, which mainly involves liver then lung tissues. cardiac involvement is very rare, especially when there is not hepatic involvement. we describe a 47-year-old woman with a history of a lung hydatid cyst who was referred to rajaei heart center, tehran, iran in 2012. her chest computed tomographic scan showed a cardiac mass. echocardiographic examination...

Working memory--including simple maintenance of information as well as manipulation of maintained information--has been long associated with lateral prefrontal cortex (PFC). More recently, evidence has pointed to an important role for posterior parietal cortex (PPC) in supporting working-memory processes as well. While explanations have emerged as to the nature of parietal involvement in workin...

The purpose of this study was to investigate the effects of non-steady locomotor activities on load predictability in two goat forelimb bones and to explore the degree to which bone curvature influences load predictability. We measured in vivo bone strains in the radius and metacarpus of juvenile goats performing a variety of natural behaviors in an outdoor arena and compared these strain magni...

glutamatergic system stimulationthe nucleus accumbens shell, may affect anxiety-related behaviors, aversive learning and memory. glutamate receptors are differentially distributed in pre- and postsynaptic sites contributing to neuronal communications.the present study aimed to examine the possible involvement of the nac shell presynaptic nmda receptors on nmda induced responses, using the eleva...

Background: Intrauterine infections (TORCH) lead to the involvement of various organs of the body of the fetus, including the eye. The aim of this study was to determine the frequency and clinical response of eye lesions to specific drugs, in infants with confirmed TORCH induced ocular lesions. Methods: This historical cohort study from 2011 to 2017, had done in Pediatrics and Ophthalmology De...

The hypothesis is summarised schematically in Fig. 1. It is proposed that mechanical deformation of the skin by needles and application of heat or electrical current leads to release of large amounts of ATP from keratinocytes, fibroblasts and other cells in skin; the ATP then occupies specific receptor subtypes expressed on sensory nerve endings in the skin and tongue; the sensory nerves send i...

We hypothesized that a 10-s rest interval (at zero load) inserted between each load cycle would increase the osteogenic effects of mechanical loading near previously identified thresholds for strain magnitude and cycle numbers. We tested our hypothesis by subjecting the right tibiae of female C57BL/6J mice (16 wk, n = 70) to exogenous mechanical loading within a peri-threshold physiological ran...