Introduction: Obese individuals have elevated levels of inflammatory and cell adhesion molecules that can critically induce the occurrence of atherosclerosis. Aerobic exercise training reduces biochemical markers and anthropometric characteristics involved in atherosclerosis. However, little is known about the effect of resistance exercise training on these biomarkers. This study aimed to inves...

Traditionally, biomarkers of aging are classified as either pro-longevity or antilongevity. Using longitudinal data sets from the large-scale inbred mouse strain study at the Jackson Laboratory Nathan Shock Center, we describe a protocol to identify two kinds of biomarkers: those with prognostic implication for lifespan and those with longitudinal evidence. Our protocol also identifies biomarke...

Copyright © 2013 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. pISSN 1226-3303 eISSN 2005-664...

Canine inflammatory bowel disease (IBD) is a heterogeneous group of chronic gastrointestinal disorders. The etiology, similar to human IBD, remains unknown. Canine IBD is diagnosed by exclusion, which is a long, time and money-consuming process due to the need of elimination of other diseases presenting with similar symptoms. Therefore, a search for a specific and sensitive marker is needed to ...

alzheimer disease (ad) is a neurodegenerative disorder and the most common form of dementia. increasing evidence suggests that alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. in vitro and animal studies have linked neuroinflammation to alzheimer's disease (ad) pathology. studie...

Coronary heart disease (CHD), characterized by inflammation and accumulation of plaques mainly comprised of lipids, calcium and inflammatory cells in the walls of coronary arteries. CHD is exacerbated by specific cardiovascular risk factors, such as obesity, diabetes mellitus, and hypertension. The current review focuses on the critical role of traditional inflammatory biomarkers, including int...

In recent years the use of faecal and serologic biomarkers has been evaluated in the diagnosis and management of inflammatory bowel disease (IBD). Faecal calprotectin (FC) has been proposed as a surrogate marker for intestinal inflammation; elevated concentrations in IBD patients have been confirmed in numerous studies. Already available rapid calprotectin tests help to differentiate between IB...

The importance of inflammation in the pathogenesis of IHD, such as, acute myocardial infarct (AMI) and coronary artery disease (CAD), has long been established. A large body of evidence suggests that inflammation plays a key role in CVD, however, the mechanisms in the various stages of the pathological process is not completely understood (Carden and Granger, 2000). Inflammation is a complex of...

Although childhood arterial ischemic stroke (AIS) is a heterogeneous disorder, most cases fall into 1 of 3 broad pathogenic categories: arteriopathic, cardioembolic, and idiopathic. The presence of an arteriopathy (cervical or cerebral) confers an increased risk of recurrent AIS. In the prospective, multicenter VIPS study (Vascular Effects of Infection in Pediatric Stroke), children with arteri...

Assessments of diseases are usually performed by a combination of clinical symptoms, signs and objective measurements. Biochemical markers of inflammation are important in evaluation of treatment of acute and chronic diseases. In this thesis we have focused on two inflammatory diseases: acute radiation proctitis and rheumatoid arthritis. We examined established and new biomarkers, with focus on...