Background: Polycystic Ovarian Syndrome (PCOS) is a pro-inflammatory condition that supports the development of metabolic aberration and ovarian dysfunction. Chronic inflammation and the increased levels of androgens in this group of patients and their impact on the immune system may increase the risk of developing malignancies, including ovarian cancer. Thus, we interacted ovarian tumor cells ...

Alzheimer's disease (AD) is the most common form of dementia and has a higher incidence in women. The main component senile plaques characteristic AD amyloid-beta (Aβ), with surrounding astrocytes contributing to degenerative process. We hypothesized that sex difference could be partially due differential astrocytic responses Aβ. Thus, effect Aβ1-40 on cell viability, inflammatory response, oxi...

Introduction  Insulin-like growth factor I (IGF-I) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. IGF-I plays the roles via the receptor (IGF-IR) signaling pathway. IGF-IR unlike IGF-I is expressed strongly in the developing liver, but much more weakly in adults. Objective:  We hypothesi...

We have shown previously that a para-inflammatory response exists at the retinal/choroidal interface in the aging eye; and this response plays an important role in maintaining retinal homeostasis under chronic stress conditions. We hypothesized that dysregulation of the para-inflammatory response may result in an overt pro-inflammatory response inducing retinal degeneration. In this study, we e...

Native collagen, acetylated collagen, collagen/10% chondroitin sulphate, collagen/2.5% hyaluronic acid and collagen/20% hyaluronic acid were implanted both as film and as sponge into rat lumbar muscle for 7 and 14 d. After 7 d implantation, all materials elicited an acute inflammatory cell response characterized by numerous polymorphs and histocytes. The cell population after 14 d was principal...

background glioblastoma is a type of brain tumor with poor response to available therapies, and shows high rate of mortality. despite remarkable advancements in our knowledge about cytogenetic and pathophysiologic features of glioblastoma, current treatment strategies are mainly based on cytotoxic drugs; however, these therapeutic approaches are facing progressive failure because of the resista...

Dragon fruit is a prebiotic source of oligosaccharides. This the first report on study that evaluates anti-inflammatory effects dragon oligosaccharides (DFO) macrophage cell line. experiment evaluated DFO both gene and protein expression levels in inflammatory response lipopolysaccharide-induced RAW 264.7 The results showed significantly inhibited prostaglandin-E2, nitric oxide, tumor necrosis ...

  Objective(s): Nowadays, COX- 2 inhibitors such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes. In response to this, medicinal chemists have attempted to synthesize new classes of COX-2 Inhibitors.   Materials and Methods: In this study, three novel analogues of thiazolidin-4-ones derivatives ...

Purpose: To investigate the therapeutic effect and underlying mechanism of hypaphorine in a cellular model non-alcoholic fatty liver disease (NAFLD).Methods: Palmitic acid (PA) was used to induce NAFLD phenotype hepatocytes. Cell viability apoptosis were evaluated by CCK-8 flow cytometry assays. Inflammatory response measured enzyme-linked immunosorbent assay (ELISA). The on lipid accumulation ...

Post traumatic stress disorder, a special disease that also accompanies with histological changes such as inflammation. In this paper we decided to review the relation between PTSD and inflammation. Stressful events causes immune system dysfunction by suppressing natural killer cells and altering levels of cytokines. Also in this condition, cytotoxic T lymphocytes results in under strained pro-...