Acute kidney injury (AKI) is a common complication during systemic inflammatory response syndrome (SIRS), a potentially deadly clinical condition characterized by whole-body inflammatory state and organ dysfunction. CD44 is a ubiquitously expressed cell-surface transmembrane receptor with multiple functions in inflammatory processes, including sterile renal inflammation. The present study aimed...

Previous studies using F1 reciprocal crosses and two parental lines of broilers show the sire is instrumental in determining the in vitro leukocyte function and cytokine/chemokine profile. Since the innate immune response is the primary means young chickens have to protect themselves, we hypothesize utilizing a novel genomics approach to select sires based on an elevated pro-inflammatory cytoki...

BACKGROUND Few data are available about the inflammatory cytokine profile of bronchoalveolar lavage (BAL) from young children with frequent wheeze. The first aim was to investigate the BAL cellular and cytokine profiles in infants with recurrent lower respiratory symptoms in whom bronchoscopy was indicated for clinical symptom evaluation. The second aim was to relate the BAL results with the hi...

Objective(s): Empagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, possesses verified anti-inflammatory and anti-oxidative stress effects against diabetic nephropathy. The present investigation aims to examine empagliflozin effects on the renal levels of high mobility group box-1 (HMGB1), a potent inflammatory cytokine, and its respective receptor toll-like receptor-4 (TLR-4) in ...

Poultry is frequently contaminated by Salmonella, a pathogen leading to human health concern worldwide. This study aimed evaluate the effect of Bacillus subtilis (BS)strain 048 (BS048) on activation, phagocytosis, sterilization, cytokine secretion, and nitrogen oxide synthesis HD11 chicken macrophages subjected Salmonella enteritidis challenge, using lipopolysaccharide treatment as negative con...

The global COVID-19 outbreak has caused a public health emergency crisis, as declared by the World Health Organization in January 2020. Periodontitis is associated with increased risk for respiratory condition; hence there biological plausibility link between periodontitis, elevated pro-inflammatory cytokines levels and COVID-19-related pulmonary problems. mechanism could be similar to what bee...

The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders their inefficacy giant-cell arteritis multiple sclerosis), providing a framework for reclassification.

Abstract One of the most characteristic clinical disease presentations severe COVID-19 is ‘Cytokine Storm,’ stemming from dysregulation immune response. This overproduction proinflammatory cytokines in response to SARS-CoV-2 responsible for Acute Respiratory Distress Syndrome (ARDS) adult patients and Multisystem Inflammatory (MIS) pediatric hospitalized with COVID-19. Pattern recognition recep...

Background and objectives: Scrophularia megalantha is a native Iranian plant. In folk remedies, the species of the genus are used to treat stomach ulcers, goiter, eczema, cancer, psoriasis, and gall; however, there is not much research about S. megalantha. The current study aimed at evaluating the therapeutic effect of Scrophularia megalantha, a medic...

Background: Cerebral sinovenous thrombosis (CSVT) is a neurovascular disorder that occurs when a blood clot develops in a vein near the brain. Evaluating the subsequent changes in inflammatory cytokines can better reveal the underlying pathogeneses. Objective: To assess the serum levels of interleukin-10 (an anti-inflammatory cytokine) and IL-17 (a pro-inflammatory cytokine) in patients with as...