We present a brief description of acute retinal necrosis, rare and severe condition that is accompanied by rapid development inflammatory occlusive events in the vasculature preceding peripheral necrotizing retinitis. Despite successful etiotropic conservative therapy, disease complicated proliferative vitreoretinopathy with high risk detachment, leading to irreversible loss sight. clinical cas...

PURPOSE Toll-like receptor 4 (TLR4) alerts cells to the presence of bacteria by initiating an inflammatory response. We hypothesize that disruption of the ocular surface barrier in dry eye enhances TLR4 signaling. This study determined whether dry eye enhances expression of inflammatory mediators in response to topically applied TLR4 ligand. METHODS A single dose of lipopolysaccharide (LPS) o...

Introduction and purpose. The main manifestation of eyelids, tear ducts, orbits disorders is a dry eye disease considered as serious that affects the quality life. Nowadays, one in ten people worldwide faces this disease. Increased workload, development multimedia technologies, hypodynamia, environmental degradation are modern causes Material methods. In work, we used an experimental model rats...

Abstract Background The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessively inherited disease resulting from loss‐of‐function mutations in ADA2, formerly named CECR1 (cat eye syndrome chromosome region, candidate 1) gene. Disease manifestations could be separated into three major phenotypes: inflammatory/vascular, immune dysregulatory, and hematologic; however, most patients...

AIM: This study aimed to determine the content of matrix metalloproteinase-9 (MMP-9) in aqueous humor (AH) eyes children with uveitis and its role during disease.
 MATERIAL AND METHODS: Twenty (20 uveitis) aged from 3 16 yr (11.253.43 on average) three congenital cataract control group were examined. The concentration MMP-9 was determined by enzyme-linked immunosorbent assay (ELISA) using ...

Meibomian gland dysfunction (MGD) is associated with evaporative dry eye syndrome, which characterized by a reduction in meibum secretion and tear film instability. Present treatments provide only temporary relief, thereby necessitating the exploration of novel therapeutic strategies for chronic treatment. This study aims to evaluate topical spironolactone, medication anti-mineralocorticoid, an...

Thyroid orbitopathy (TO) is an autoimmune disease that is complicated by ocular surface disorders, leading to discomfort. Dry eye is very prevalent in patients with TO. Recent studies on the pathogenesis of dry eye have focused on the inflammatory process, and some supporting evidence has been discovered. Because TO is a disorder of autoimmune origin, we assumed that the association between TO ...

Background: Detection and treatment of syphilitic ocular disease without a known history syphilis is often difficult due to its varied presentations. Early diagnosis are the key reducing risk permanent vision loss, particularly with optic nerve retinal manifestations. Case Report: This case report describes 44 year-old male who was diagnosed neurosyphilis through his work-up for unilateral neur...

introduction due to limitation of colonoscopy in assessing the entire bowel and patients’ intolerance in inflammatory bowel disease (ibd), in the current study, we aimed to prospectively compare the accuracy of 99m tc(v)-dimercaptosuccinic acid (dmsa) and fecal calprotectin with ileocolonoscopy as new methods for localizing inflammations. methods current prospective study conducted between 2012...