Based on positive results from the Radiation Therapy Oncology Group (RTOG) 85-01 trial, the conventional nonsurgical treatment of esophageal carcinoma is combined-modality therapy. Dose intensification of the RTOG 85-01 regimen, examined in the Intergroup (INT)-0123/RTOG 94-05 trial, did not improve local control or survival. Areas of clinical investigation include the development of combined-m...

Purpose The side effects and sequelae related to anti-tumor therapy regularly result in extensive physical, psychosocial and mental impairments in the life of children after therapy of a brain tumor. Although some supportive therapies are available, there are still numerous unsolved chronic problems. Therefore innovative additional therapeutic approaches from the field of complementary medicine...

Periodontal attachment loss in the maxillary anterior region can often lead to esthetic and functional clinical problems. Lifelong motivation is essential to the supportive therapy for these patients, and the maintenance of good esthetics, combined with conducive to maintaining long term dental and professional health. This paper aims to demonstrate an innovative treatment option for dealing wi...

This multicenter study was carried out on a population of female patients suffering from lower back pain due to a recent vertebral fracture. The painful symptoms were controlled using an innovative, medium frequency and constant intensity analgesic current, known as Horizontal Therapy. The double blind results were compared with Interferential Current therapy and a placebo. This joint study was...

During the PhD, the candidates develop a scientifi c research project dealing with a complex problem (which can be at different scales, from the molecular and the cellular levels to living organisms up to biomedical systems) and investigate original methods, devices, and systems with different purposes: increasing knowledge, proposing innovative methods for diagnosis and therapy as well as impr...

Chronic heart failure is a severe clinical syndrome among the most remarkable for prevalence and morbidity in the developed western countries. The European STREP project HEARTFAID aims at realizing an innovative platform of services which will improve the processes of diagnosis, prognosis and therapy provision in the heart failure domain. The core of the platform intelligence is a Clinical Deci...

periodontal regeneration in a one-wall intrabony defect is a challenging and complex phenomenon. the combination therapy of commercially available bone grafts with the innovative tissue engineering strategy, the platelet rich plasma, has emerged as a promising grafting modality for two and three walled intrabony osseous defects. the application of this combination approach was attempted in a mo...