نتایج جستجو برای: insulin genetics
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background: understanding the differences in genetics of malignancies is crucial for therapeutic decisions. this systematic review was conducted to evaluate the current evidence on genetics of bone tumors in the context of pediatric cancer. material and methods: we performed a systematic review of the literature published on genetics of pediatrics bone tumors, using pubmed, google scholar, scie...
Polycystic ovarian syndrome can be defined as an endocrine disorder that most affects the reproductive system of women childbearing age; its causes are not exactly known. However, majority experts agree it is a multifactorial entity with multiple factors. Genetics becoming increasingly important. In recent years, several genes involved in pathogenic processes this have been identified. Within t...
Inbred mouse strains provide genetic diversity comparable to that of the human population. Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse strains differ in the response of their critical physiological functions, such as insulin sensitivity, insulin secretion, beta-cell proliferation and survival, and fuel partitioning, to diet and obesity. Most of the criti...
Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain only 15% of the heritability. In an attempt to identify additional T2D genes, we analyzed global gene expression in human islets from 63 donors. Using 48 genes located near T2D risk variants, we identified gene coexpression and protein-protein interaction networks that were strongly associated with islet ...
INTRODUCTION Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our cont...
Diets high in carbohydrates have long been linked to progressive heart dysfunction, yet the mechanisms by which chronic high sugar leads to heart failure remain poorly understood. Here we combine diet, genetics, and physiology to establish an adult Drosophila melanogaster model of chronic high sugar-induced heart disease. We demonstrate deterioration of heart function accompanied by fibrosis-li...
As an essential nutrient, Selenium (Se) is involved in many metabolic activities including mimicking insulin function. Data on Se in various biological samples and insulin resistance are contradictory, moreover there is no large study available regarding the relationship of dietary Se intake with insulin resistance in the general population. To investigate the association between dietary Se int...
background: the quantitative analysis of scientific output, scientific policy making, scientific relationships of researchers, and drawing historiographic outlines are all parts of scientometric discipline. this paper was designed for scientometric analysis of 20 top journals in the field of genetics and heredity in 2000-2008 and to map the scientific structure of their papers. methods: this re...
complex inherited diseases affected by an interaction between collective effects of the genotype at one or multiple loci either to increase or to lower susceptibility to disease, combined with a variety of environmental exposures that may trigger, accelerate, exacerbate, or protect against the disease process. the new aspects of genetic techniques have been opened for diagnosis and analysis of ...
background: middle east respiratory syndrome (mers) is a viral respiratory illness caused by a coronavirus. after the primary onset of mers in saudi arabia, in september 2015 cases began to increase. the number of laboratory-affirmed cases by mers-cov in the middle east has been being increased recently. method: in this current review article, by using the terms “mers” and “coronavirus” we firs...
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