Recent findings have revealed that dysregulated miRNAs contribute significantly to autophagy and chemoresistance. Pharmacologically targeting autophagy-related miRNAs is a novel strategy to reverse drug resistance. Here, we report a novel function of isoliquiritigenin (ISL) as a natural inhibitor of autophagy-related miR-25 in killing drug-resistant breast cancer cells. ISL induced chemosensiti...

Through a National Science Foundation (NSF) grant, the authors have forged an interdisciplinary effort to integrate graduate and undergraduate research, curriculum, and outreach projects that promote service learning in robotics and intelligent systems. The authors have founded the Institute for Research in Intelligent Systems (IRIS) and the Intelligent Systems Lab (ISL) as advisory and resourc...

Contrast degradation is a critical problem in ultrasound plane wave imaging (PWI) resulting from signals leakage from the sidelobes. An ideal sidelobe reduction method may enhance the contrast without remarkably increasing computational load. To this end, we introduce a new singular value decomposition (SVD) sidelobe reduction beamformer for coherent plane wave compounding (CPWC) based on a pre...

AOTF, acoustooptic filter, lithium niobate, integrated optics A two-section integrated acoustooptic tunable filter with significantly reduced sidelobes has been fabricated. The sidelobe reduction was achieved using birefringence apodization in the form of variable width Ti stripe waveguides. The design and fabrication of the device, which includes integrated proton exchanged TE and TM pass pola...

Kisspeptin and the G protein-coupled receptor 54 (GPR54) are highly abundant in the pancreas. In addition, circulating kisspeptin directly influences insulin secretion through GPR54. However, the mechanisms by which kisspeptin affects insulin release are unclear. The LIM-homeodomain transcription factor, Isl-1, is expressed in all pancreatic islet cells and is involved in regulating both islet ...

Immature rat intestinal stem cells (IEC-6) given the ability to express the transcription factor, pancreatic duodenal homeobox 1 (Pdx-1), yielded YK cells. Although these cells produced multiple enteroendocrine hormones, they did not produce insulin. Exposure of YK cells to 2 nmol/l betacellulin yielded BYK cells that showed the presence of insulin expression in cytoplasm and that secreted insu...

Dieses Verfahren wird in dem am ISL entwickelten View4You−System [2], [10] eingesetzt, welches mittels Spracherkennung Transkripte der ARD−Tagesschau erzeugt. In diesen kann dann ein Benutzer, ebenfalls per Spracheingabe, suchen lassen, um die in Bezug auf ein bestimmtes Thema relevanten Meldungen zu finden. Diese kann er dann über eine einem Web−Browser ähnliche Schnittstelle in Bild und Ton b...

A new class of modular broadband low-sidelobe arrays, based on the theory of fractile (fractal tile) geometry, has been recently introduced. In this paper, the radiation properties of the Peano–Gosper fractile array are compared to those of the conventional square and hexagonal arrays. It is demonstrated that the Peano–Gosper array has the same desirable grating-lobe conditions as the hexagonal...

Sequences with good correlation properties are in general required in various applications such as radar, sonar, spread spectrum and multiple access communication. The optimal sequences are the ones whose peak sidelobe of the aperiodic autocorrelation function is the minimum possible for a given sequence length. A chaotic sequence that provides auto and cross-correlation properties that are sim...

This paper presents a cross platform multilingual multimedia Indian Sign Language (ISL) dictionary building tool. ISL is a linguistically under-investigated language with no source of well documented electronic data. Research on ISL linguistics also gets hindered due to a lack of ISL knowledge and the unavailability of any educational tools. Our system can be used to associate signs correspondi...