نتایج جستجو برای: intermediate β
تعداد نتایج: 306377 فیلتر نتایج به سال:
BACKGROUND In sepsis, tachycardia may indicate low preload, adrenergic stimulation, or both. Adrenergic overstimulation is associated with septic cardiomyopathy. We sought to determine whether tachycardia was associated with left ventricular longitudinal strain, a measure of cardiac dysfunction. We hypothesized an association would primarily exist in patients with high preload. METHODS We pro...
Amyloid formation is implicated in more than 20 human diseases, yet the mechanism by which fibrils form is not well understood. We use 2D infrared spectroscopy and isotope labeling to monitor the kinetics of fibril formation by human islet amyloid polypeptide (hIAPP or amylin) that is associated with type 2 diabetes. We find that an oligomeric intermediate forms during the lag phase with parall...
Accumulating evidence suggests that various neurodegenerative diseases, including Alzheimer's disease (AD), are linked to cytotoxic diffusible aggregates of amyloid proteins, which are metastable intermediate species in protein misfolding. This study presents the first site-specific structural study on an intermediate called amylospheroid (ASPD), an AD-derived neurotoxin composed of oligomeric ...
Abstract The rational design based on a deep understanding of the present reaction mechanism is an important, viable approach to discover new organic transformations. β -Hydrogen elimination from palladium complexes fundamental in catalysis. Normally, eliminated β- hydrogen has be attached sp 3 -carbon. We envision that 2 -carbon possible by using thoroughly designed systems, which may offer st...
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