نتایج جستجو برای: international harmonization

تعداد نتایج: 311925  

Journal: :Scientific Research of Faculty of Economics. Electronic Journal 2017

Journal: :Toxicologic pathology 2012
Daniel Rudmann Robert Cardiff Luc Chouinard Dawn Goodman Karin Küttler Heike Marxfeld Alfredo Molinolo Silke Treumann Katsuhiko Yoshizawa

The mammary gland of laboratory rodents is an important organ for the evaluation of effects of xenobiotics, especially those that perturb hormonal homeostasis or are potentially carcinogenic. Mammary gland cancer is a leading cause of human mortality and morbidity worldwide and is a subject of major research efforts utilizing rodent models. Zymbal's, preputial, and clitoral glands are standard ...

Journal: :Laboratory animals 2013
M Rose J Everitt H Hedrich J Schofield M Dennis E Scott G Griffin

Replacement, Reduction and Refinement, the ‘Three Rs’ of Russell & Burch, are accepted worldwide as fundamental to the ethics of animal experimentation. The production, care and use of genetically-altered animals can pose particular challenges to the implementation of the Three Rs,1 necessitating additional considerations by those responsible for overseeing the ethical use and appropriate care ...

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