Brain tumor invasion leads to recurrence and resistance to treatment. Glioma cells invade in distinct patterns, possibly determined bymicroenvironmental cues including chemokines, structural heterogeneity, and fluid flow. We hypothesized thatfloworiginating frompressure differentials between the brain and tumor is active in glioma invasion. Using in vitromodels, we show that interstitial flow p...

Microscale assays of protein, glucose, lactate (LA), and the total lactic dehydrogenase (LDH) activity in samples of free interstitial fluid from solid unicentric tumor transplants in mice are reported. The values have been compared with those found in plasma and intraperitoneal fluid from normal and tumor-bearing mice. The tumor fluids contained greater amounts of protein, LA, and LDH than did...

A full-length complementary DNA (cDNA) for interstitial collagenase was isolated from an A2058 melanoma cDNA library using the pCD-X Okayama-Berg vector. The tumor interstitial collagenase cDNA was sequent-eeland compared to the published sequences for human fibroblast collagenase. The sequence for the tumor collagenase has two DNA base pairs which differ from the sequence of normal fibroblast ...

PURPOSE To investigate tumor interstitial fluid pressure as a prognostic factor for recurrence-free survival in patients with cervical cancer following radiation therapy. EXPERIMENTAL DESIGN Tumor interstitial fluid pressure was measured in 55 cervical cancer patients who received radiation therapy between August 1998 and September 2002. Interstitial fluid pressure measurements were made befo...

purpose: to define the demographic and clinical features of eyelid masses at a referral hospital over a 10-year period. methods: this is a retrospective record-based study on patients with eyelid masses during the above-mentioned period. data on epidemiologic and clinical features and therapeutic approaches were collected and analyzed. results: 551 patients were included in the study from which...

Interstitial cell carcinoma of the testis is a singularly rare steroid-producing cancer. Of the seven reported cases (1-7), urinary 17-ketosteroid (17KS) excretion was high in the four cases in which it was measured. Abelson, Bulaschenko, Trommer, and Valdes-Dapena (7) fractionated the urinary 17-ketosteriods and corticoids in one recently reported case. There is, however, no comprehensive stud...