Using genetically homogeneous inbred ACI and Fischer rats, the author has conducted active immunization with the skin and lymphoid cells from ACI rat to Fischer rat and succeeded in making an experimental model that unfailingly causes hyperacute rejection, which has heretofore been considered to be extremely difficult. Semipermanent survival was gained with syngenetic graft. With allograft, acu...

The role of NKT cells during immune responses is diverse, ranging from antiviral and antitumor activity to the regulation of autoimmune diseases; however, the regulatory function of CD1d-dependent NKT cells in rejection responses against allogeneic graft is uncertain. In this study, we demonstrated the direct regulatory effects of CD1d-dependent NKT cells using an allogeneic skin transplantatio...

We have devised a technique of two-stage tracheal reconstruction using S-shaped skin flaps and an aural conchal cartilage graft. During the first operation, S-shaped skin flaps were elevated before resection of the trachea. A tracheocutaneous fistula was created at the tracheal defect using S-shaped skin flaps while placing the conchal cartilage graft underneath. During the second operation, a ...

With what types of hand injuries can vacuum-assisted closure (VAC) be used? Large wounds with an insufficient bed for skin grafting are most helped with VAC therapy. The negative-pressure environment of VAC helps decrease swelling, remove exudate, promote granulation tissue, and shrink the size of the wound. If a skin graft is applied to a hand wound, VAC application can promote adherence of th...

Irradiated and thymectomized CBA mice are markedly depressed in several immunological parameters (skin homograft rejection, graft-vs.-host activity and hemolytic plaque-forming cells of the spleen, hemolysin and hemagglutinin formation, and peripheral lymphocyte counts). In the present experiments the ability of homografts of neonatal thymus placed beneath the kidney capsule to restore immunolo...

In I896, Krause reported the use of the same type of graft in a large series of cases and described in great detail a technique which differs little from that employed to-day. In view of this work, in which full credit was given to the earlier reports of Wolfe and others, it is not unreasonable that this graft should be named, as it frequently is, the Wolfe-Krause graft. " Full-thickness," " De...

Background: To examine in an experimental animal study whether alginate microencapsulation of allogeneic parathyroid tissue succeeds by protecting the graft against the host’s activated immune system or by delaying immunization of the host. Methods: Lewis and Dark Agouti rats (n = 200 of each) were used. Parathyroidectomy (PTX) of the hosts was followed by allogeneic transplantation of microenc...

In contrast to the uniform rejection of adult male skin isografts by C57BL/6 females, neonatal male skin isografts are frequently accepted. Moreover, 50% of all females which accept a neonatal male skin graft for 50 days accept a subsequent adult male skin graft as well. This ability of neonatal skin to produce tolerance has been investigated under a variety of experimental conditions. The resu...

Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal antibodies can lead to a robust state of peripheral "dominant" tolerance. Regulatory CD4+ T cells, which mediate this form of "dominant" tolerance, can be isolated from spleens of tolerant animals. To determine whether there were any extra-lymphoid sites that might harbor regulatory T cells we sought their p...