BACKGROUND & AIMS Hirschsprung disease (HSCR) is caused by failure of cells derived from the neural crest (NC) to colonize the distal bowel in early embryogenesis, resulting in absence of the enteric nervous system (ENS) and failure of intestinal transit postnatally. Treatment is by distal bowel resection, but neural cell replacement may be an alternative. We tested whether aneuronal (aganglion...

BACKGROUND Hirschsprung's disease (HSCR) is one the most common congenital intestinal disease. It leads to aganglionic megacolon in the early childhood. Several susceptibility genes have been identified : RET protooncogene and its ligand, glial cell derived neutrophic factor (GDNF), Sox 10, Endothelin-3 (EDN3) and its receptor B (EDNRB). EDNRB mutations are found in 5% of familial or sporadic H...

Hirschsprung disease-associated enterocolitis (HAEC) leads to significant mortality and morbidity, but its pathogenesis remains unknown. Changes in the colonic epithelium related to goblet cells and the luminal mucus layer have been postulated to play a key role. Here we show that the colonic epithelium of both aganglionic and ganglionic segments are altered in patients and in mice with Hirschs...

ashkan kavyani1, ahmad zare shahne1, javad pourreza1, sayed mohammad ali jalali haji-abadi1, mohsen nikkhah2, nasir landy 3*  1- department of animal science, shahrekord branch, islamic azad university, shahrekord, iran 2 -department of animal science, faculty of agriculture, university of guilan, iran 3-young researchers and elite club, khorasgan branch, islamic azad university, isfahan, iran ...

Background: Hirschsprung’s disease is a congenital caused by the absence of ganglion cellsin bowel wall, which results in functional obstruction aganglionic segment due to failure ofrelaxation during peristalsis. The recto-sigmoid index on barium enema may constitute diagnosis ofHirschsprung’s disease.Aim: To evaluate sensitivity, specificity, positive predictive value, and negative value ofrec...

prevalence of various intestinal helminthiasis has been established among the population of 42 villages in gonbad kavus in the north-east of the caspian littoral during a longitudinal health survey undertaken in this area. stool examination by formaline ether technique been performed among 1240 randomly selected population. surprisingly and contrary to most other areas in iran; very low infecti...

the purpose of this study was to investigate the status and epidemiology of intestinal parasites in iran. the information was driven from an extensive health survey which was done by the ministry of health and medical education, deputy of research affairs in 1990-92. sampling fraction was 1 per 1000 of individuals aged between 2 and 69, the sampling method was cluster sampling and each cluster ...

intraluminal small bowel hematoma has been rarely reported in children, as a rare cause of small bowel obstruction. we present a case of an intraluminal ileal hematoma presenting as small bowel obstruction in a child. computed tomography (ct) indicated a large intraluminal hyperdense lesion in the distal ileum as the cause of small bowel obstruction. abdominal ultrasonography (us) showed an ech...

background: for a long time, intestinal parasite infections are among the major problems of public health in iran. our aim was epidemiological studies on the frequency of intestinal parasites in patients re­ferred to three hospitals in tehran during 2007-2008. methods : during 2007-2008, by simple random selection, 1000 stool samples were collected from mi­lad, hazrat-e-rasoul and shahid fahmid...

Intestinal obstruction may be duo to various mechanical or functional reasons. Worms, especially Ascaris worms are one of the mechanical reasons of intestinal obstruction. Obstruction due to Taenia saginata is a rare phenomenon. Here we report a case of intestinal obstruction due to Taenia saginata infection in a 30 year-old male patient undergoing laparatomy with the diagnosis of intestinal ob...