LETTERS Spontaneous venous pulsations should be monitored during glaucoma therapy It is well established that lowering intraocular pressure slows or halts progression of glau-coma. None the less, changes in intracranial pressure also affect the pressure gradient across the lamina cribrosa. Normal intraocu-lar pressures combined with low intracranial pressures produce the same pressure different...

n engl j med 367;8 nejm.org august 23, 2012 746 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presente...

Thiopentone was administered in bolus doses (1.5–3.0 mg/kg) 26 times to 18 neurosurgical patients undergoing craniotomy. Intracranial pressure and blood pressure responses to thiopentone were evaluated and the cerebral perfusion pressure calculated. Thiopentone given 21 times to treat chronic or acutely elevated intracranial pressure significantly reduced the mean pressure from 40 1.5 to 22 1.4...

Chronic fatigue syndrome and cases of idiopathic intracranial hypertension without signs of raised intracranial pressure can be impossible to distinguish without direct measurement of intracranial pressure. Moreover, lumbar puncture, the usual method of measuring intracranial pressure, can produce a similar respite from symptoms in patients with chronic fatigue as it does in idiopathic intracra...

CT scan findings, clinical features and intracranial pressure were studied in patients with severe diffuse head injury. Compression of the 3rd ventricle and basal cisterns closely correlated with an intracranial pressure greater than 20 mmHg, with clinical signs of midbrain dysfunctions and worse prognosis. These CT scan findings can indicate whether intracranial pressure monitoring is appropri...

The pathophysiology of acute mountain sickness and high-altitude cerebral edema, the cerebral forms of high-altitude illness, remain uncertain and controversial. Persistently elevated or pathological fluctuations in intracranial pressure are thought to cause symptoms similar to those reported by individuals suffering cerebral forms of high-altitude illness. This review first focuses on the basi...

OBJECTIVE In children with acute CNS infection, management of raised intracranial pressure improves mortality and neuromorbidity. We compared cerebral perfusion pressure-targeted approach with the conventional intracranial pressure-targeted approach to treat raised intracranial pressure in these children. DESIGN Prospective open-label randomized controlled trial. SETTING PICU in a tertiary ...