Background Previous animal model studies from Sukumar and others demonstrated the effect of intraductal administration of cytotoxic agents in preventing the occurrence of breast cancer. To determine the feasibility of the approach in humans, a preliminary study was performed in patients who were diagnosed with breast cancer and were waiting for mastectomy. Two drugs, carboplatin and Pegylated L...

In recent years, the disease concept of intraductal papillary neoplasm of the bile duct (IPNB) has been attracting attention as a biliary lesion that is morphologically similar to intraductal papillary mucinous neoplasm (IPMN), which is considered to be a counterpart of IPMN. However, there are few reports on IPNB, and a consensus regarding the features of this disease is thus lacking. We exper...

We report a case of a 67-year-old Caucasian man with right upper quadrant abdominal pain. He underwent radiologic investigations that revealed a solid, focal mass, at the V hepatic segment. Because a definitive diagnosis, based on imaging appearance of the lesion, was impossible in our case, we performed a hystopathological investigation but the biopsies were inconclusive. So, the definitive di...

Intraductal papillary mucinous neoplasms are known malignant lesions of pancreas but recently a similar tumor has been reported and recognized by WHO in 2010 which involves the bile ducts. The involvement of common bile duct by this malignant tumor is extremely rare. Intraductal papillary mucinous tumors of bile ducts have been found to have much better prognosis than the other cholangiocarcino...

Pancreatic endocrine tumors are rare tumors classified into "functioning" and "nonfunctioning" tumors. A 68-year-old man was admitted to our hospital with the chief compliant of abdominal pain. Various imaging studies demonstrated a mass in the head of the pancreas with intraductal growth into the main pancreatic duct and an intraportal mass. The patient underwent a curative surgical operation....

Breast carcinoma in men is extremely rare; it represents 0.6% of all breast carcinomas and less than 1% of all malignancies in men [1]. Intraductal papillary carcinoma (IPC) is also a rare form of breast cancer, accounting for 0.5–1% of all breast cancers [2]. IPC in man is an extremely rare disease with only very few case reports published in the literature so far [3-5]. IPC accounts for 5 to ...

We report a rare case of intraductal lipid-rich carcinoma of the breast with a component of glycogen-rich carcinoma. An impalpable tumor that was revealed by mammography and magnetic resonance imaging was excised. Histologic examination showed vacuolated neoplastic cells in the mammary ducts, and electron microscopy confirmed lipid droplets in the cytoplasm. The coexistence of glycogen-rich car...

BACKGROUND The prevalence of carcinoma in main-duct intraductal papillary mucinous neoplasm (IPMN) is high, and surgical resection is recommended for all patients with a main-duct IPMN. RESULTS A main-duct IPMN with typical imagings including protruding lesions in the dilated main pancreatic duct was resected, but the histology was intraductal papillary mucinous adenoma of the pancreas. DIS...

INTRODUCTION Primary osteosarcoma of the breast is extremely rare, and an osteosarcoma arising from an intraductal papilloma is exceptional. CASE PRESENTATION A 72-year-old Saudi Arabian woman presented with a solid, bone-containing breast mass that was diagnosed as primary osteosarcoma of the breast on biopsy. She had a history of untreated intraductal papilloma. Treatment was completed with...

Abbreviations: EVG, elastic van Gieson; MRI, magnetic resonance imaging; PAS, periodic acid-Schiff Mammary Paget’s disease is usually localized in the nipple epidermis and lactiferous duct near the nipple (Lloyd et al., 2000). Breast conservative therapy has been attempted for such a patient (Pierce et al., 1997). However, this method may not be appropriate for all patients with Paget’s disease...