BACKGROUND AND PURPOSE Bacteriophages, viruses that cause lysis of bacteria, can serve as an effective tool for the control of infections, especially those caused by multiple drug-resistant organisms. Klebsiella pneumoniae is one of the most predominant pathogens associated with burn wound infections, causing considerable morbidity and mortality. This study investigated the protective effect of...

bearing L1210 or L1210/MTX leukemia to study DNA synthesis in vivo. In mice bearing a large population of leukemia cells, most of the retained radioactivity could be recovered from the DNA of these cells. Total body retention and the anatomical distribution of radioactivity in leukemic mice were highly dependent upon the route of iododeoxyuridine administration. Intraperitoneal injections into ...

Given the extensive application of carbon nanotubes (CNTs) in biomedical fields, there is increasing concern regarding unintentional health impacts. Research into safe usage is therefore increasingly necessary. This study investigated the responses of the mouse brain to single-walled CNTs (SWCNTs) delivered via intraperitoneal (IP) injection and compared these results with the previous study wh...

Mice were vaccinated with an attenuated encephalomyocarditis (EMC) virus strain by the intraperitoneal (i.p.) route and by various ways of respiratory administration: aerosol exposure and intratracheal (i.t.) and intranasal (i.n.) instillation. A linear relationship was found between vaccine dose and the resulting serum antibody titer. The effectiveness of the vaccine was determined by measurin...

Mice compromised by a burn wound injury and subjected to a fatal infection with Pseudomonas aeruginosa were administered a single dose of a Pseudomonas aeruginosa phage cocktail consisting of three different P. aeruginosa phages by three different routes: the intramuscular (i.m.), subcutaneous (s.c.), or intraperitoneal (i.p.) route. The results of these studies indicated that a single dose of ...

BACKGROUND Rift Valley fever (RVF) is a severe mosquito-borne disease affecting humans and domestic ruminants. Mosquito saliva contains compounds that counteract the hemostatic, inflammatory, and immune responses of the host. Modulation of these defensive responses may facilitate virus infection. Indeed, Aedes mosquito saliva played a crucial role in the vector's capacity to effectively transfe...

Ovarian cancer has the highest mortality of all gynecologic malignancies in the United States. Ovarian cancer is often diagnosed at advanced stage. Optimal cytoreduction, followed by intravenous chemotherapy consisting of platinum taxol containing agents represents the mainstay of ovarian cancer therapy. The introduction of intraperitoneal chemotherapy utilized a novel route of administration s...

BACKGROUND The development of mucosal vaccines is crucial to efficiently control infectious agents for which mucosae are the primary site of entry. Major drawbacks of these protective strategies are the lack of effective mucosal adjuvant. Synthetic oligodeoxynucleotides that contain several unmethylated cytosine-guanine dinucleotide (CpG-ODN) motifs are now recognized as promising adjuvants dis...