Midazolam is a short-acting benzodiazepine that is widely used in anesthesia. Despite its widespread clinical use, detailed information about cardiac side effects of midazolam is largely lacking. Using the double-electrode voltage clamp technique, we studied pharmacological effects of midazolam on heterologously expressed Kv1.5 channels underlying atrial repolarizing current I(Kur). Midazolam d...

The 30-minute ratio of 1'-hydroxymidazolam:midazolam plasma concentrations has been used as a measure of midazolam clearance in liver transplant patients. This study determined if a single concentration of 1'-hydroxymidazolam or the ratio of 1'-hydroxymidazolam:midazolam could be used to predict midazolam clearance in healthy subjects. Plasma midazolam and 1'-hydroxymidazolam concentrations fro...

introduction: both midazolam and promethazine are recommended to be used as sedatives in many studies but each have some side effects that limits their use. combination therapy as an alternative method, may decreases these limitations. therefore, this study aimed to compare midazolam with midazolam-promethazine regarding induction, maintenance, and recovery characteristics following pediatric p...

Midazolam is almost exclusively metabolized by cytochrome P450 3A (CYP3A) isoenzymes. Therefore, midazolam is used as a probe to determine CYP3A levels in humans and rats. A prerequisite for longitudinal determination of CYP3A expression levels using midazolam as a probe is that midazolam itself has no effect on the expression of CYP3A. In the present study, we analyzed the mRNA levels and enzy...

BACKGROUND Midazolam may suppress conditioned fear after an aversive event by disrupting the memory trace formed during conditioning, by altering the emotional part of the aversive event, or by the combination of both effects. The purpose of the present study was to determine whether affective-related processes contribute to the amnesic-like effects of midazolam on aversive events. METHODS Th...

BACKGROUND Soman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as infection, hemodynamic instability and hypoxia. We investigated whether midazolam protects the Central Nervous System (CNS) from soman intoxication. The present study w...

Abstract Objective To systematically review the evidence for intrathecal or intraventricular plus intravenous administration of antibiotics compared with standard management postsurgical meningitis ventriculitis. Methods The following databases were searched: MEDLINE, Central Register Controlled Trials (CENTRAL); PubMed, EMBASE; and reference list articles. Results Administration intrathecal/in...

intrathecal injection of sufentanil with adrenalin was performed in 45 cases (20 female, 25 male age range: 18-40 years). all injections were performed in the sitting position, with a number 20 intrathecal needle immersed in adrenalin. the cases were observed for 72 hours. maximum duration of analgesia was 12 hours (60%) and the minimum was 3 hours (13.3%). this method reduces the need for repe...

conclusions conservative management is successful in the vast majority of patients with spinal headache. interventional procedures are required in a small fraction of patients for symptomatic relief. case presentation intrathecal drug delivery system (idds) was initially used for the management of chronic malignant pain; it has since been used to manage pain from other nonmalignant conditions a...