There is a growing body of evidence that improper intrauterine nutrition may negatively influence vascular health in later life. Maternal malnutrition may result in intrauterine growth retardation and, in turn, metabolic disorders such as insulin resistance, diabetes, hypertension, and dyslipidemia, and also enhanced risk of atherosclerosis and cardiovascular death in the offspring. Energy and/...

to determine the prevalence of asherman's syndrome in the south of iran and assess the safety and efficacy of hysteroscopic adhesiolysis in restoration of menstrual function and fertility, a prospective study was done from 1997 to 1999. among 2300 couples with infertility referring to the infertility clinic of a shiraz university hospital, 30 patients were proven to have asherman's sy...

background: leiomyomata is the most frequent gynecological neoplasm. one of the major complications of myomectomy is intrauterine adhesion (synechiae). objective: to evaluate and compare the rate and severity of synechiae formation after myomectomy by laparotomy and laparoscopy. materials and methods: in this non-randomized interventional trial, hysteroscopy was performed in all married fertile...

background: controlled ovarian stimulation combined with intra uterine insemination (iui) is a convenient treatment of infertility with a success rate of 11%. the clinical observation and pattern of progesterone secretion in this method is suggestive of luteal phase defect and postulated as an implicating factor of treatment failure. objective: to investigate the efficacy of luteal phase suppor...

Compelling epidemiological evidence suggests that exposure to an adverse intrauterine environment, manifested by low-birth weight, is associated with cardiometabolic and behavioural disorders in adulthood. These observations have led to the concept of 'fetal programming'. The molecular mechanisms that underlie this relationship remain unclear, but are being extensively investigated using a numb...

The developmental origins of disease or fetal programming model predict that early exposures to threat or adverse conditions have lifelong consequences that result in harmful outcomes for health. The maternal endocrine 'fight or flight' system is a source of programming information for the human fetus to detect threats and adjust their developmental trajectory for survival. Fetal exposures to i...

It is now well accepted that offspring exposed to maternal undernutrition, obesity, or gestational diabetes mellitus have an increased risk for chronic diseases later in life, supporting the theory of the early origins of chronic diseases. However, the molecular mechanisms through which the exposure to an altered in utero environment translates into the development of chronic diseases are not y...

Being born small-for-gestational age and a rapid increase in weight during early childhood and infancy has been strongly linked with chronic diseases, including metabolic syndrome, which has been related to intrauterine life environment and linked to epigenetic fetal programming. Metabolic syndrome includes waist circumference ≥ 90(th) percentile for age, sex and race, higher levels of blood pr...

background: in this study, we examined the epidemiological aspects of neonatal mortality due to intrauterine infections with regard to regional characteristics. methods: consolidated report of the ministry of health and social development of the republic of kazakhstan on children deceased during their first 28 days of life due to intrauterine infections (p23 – congenital pneumonia, p35-39 – inf...