Background: Blood loss during and immediately after total knee arthroplasty (TKA) is among the most challenging concerns. It has been demonstrated that Tranexamic acid (TXA) can help to reduce perioperative blood loss. TXA can be used as an oral, topical or intravenous injection. Many studies evaluated the effectiveness of each route of administration but few works on a comparison between them....

Monte Carlo simulation was used to assess the type I error rate and rank order of power for six different metrics using linear mixed-effect models, including two variables recommended by the European Agency for the Evaluation of Medicinal Products (EMEA) in the analysis of QTc interval data. The metrics analyzed were maximal change in QTc interval from baseline, maximal QTc interval, area under...

conclusions administration of intravenous acetaminophen before ending appendectomy might be more effective than meperidine in postoperative pain management while having fewer complications. patients and methods in this randomized clinical trial study, forty patients with asa- class i or ii who were candidates for emergency appendectomy were randomly divided into two groups. induction and mainte...