The contribution of the lung to drug metabolism was investigated in rats and the possibility of prediction of in vivo metabolism from in vitro studies using rat pulmonary microsomes was assessed. Lidocaine, midazolam, or nifedipine was administered to rats at a dose of 10 mg/kg by the intra-arterial, intravenous, and intraportal routes. The pulmonary extraction ratios of lidocaine, midazolam, a...

For the past 50 years, local anesthetics such as lidocaine have been commonly used in various clinical settings. Its use is not just limited to anesthesia and surgery but is also frequently utilized in internal medicine and in primary care setting for bedside procedures. Despite its widespread use, most physicians are not familiar with the life-threatening manifestations of lidocaine toxicity a...

BACKGROUND The authors' previous study demonstrated that a clinical antiarrhythmic dose of lidocaine, when given before ischemia, is neuroprotective in a rat model of transient focal cerebral ischemia. In this study, the authors investigated whether the administration of this dose of lidocaine, when delayed until 45 min after the onset of ischemia, also reduces ischemic brain injury. METHODS ...

Heart, Lung and Vessels. 2014, Vol. 6 Corresponding author: Paolo Grassi, M.D. Department of Anesthesia and Intensive Care Azienda Ospedaliero-Universitaria “Ospedali Riuniti” 34142 Trieste, Italy e-mail: [email protected] Obtaining adequate analgesia after major surgery is a problematic issue and postoperative pain still imposes a major burden of suffering on surgical patients (1...

Case reports demonstrating a return to sinus rhythm from sustained ventricular tachycardia (VT) are limited. VT is uncommon in horses but can be life threatening and has been reported with primary gastrointestinal disease. Treatment recommended if there poor perfusion, heart rate exceeds 100 beats/min, multiform/polymorphic complexes or torsades des pointes present. Lidocaine magnesium sulfate ...

In this study, the duration of the QRS complex during ventricular pacing was used as an index of intraventricular conduction to quantitate the rate-dependent effects of intravenous lidocaine, procainamide and amiodarone. Right ventricular apical pacing (15 to 20 beats) was performed at cycle lengths of 600, 500, 400, 350, 300, 275 and 250 ms, before and 5 minutes after the intravenous administr...

With great interest we read the article of Kashani and colleagues “Intra-articular lidocaine versus intravenous sedative and analgesic for reduction of anterior shoulder dislocation”.1 This article that has been recently published in your journal describes the interesting results of a randomized controlled trial that compared intraarticular lidocaine with intravenous sedation for the treatment ...

BACKGROUND This study was done to evaluate the effect on pain relief when acetaminophen was added to lidocaine for intravenous regional anesthesia (IVRA). METHODS SIXTY PATIENTS UNDERGOING HAND OR FOREARM SURGERY RECEIVED IVRA WERE ASSIGNED TO THREE GROUPS: Group C received 0.5% lidocaine diluted with 0.9% normal saline to a total volume of 40 ml (n = 20), Group P received 0.5% lidocaine dilu...

The aim of this study was to determine the effects of lidocaine (LIDO) and dexmedetomidine (DEX) or their combination (LIDO-DEX), administered by constant-rate infusion (CRI), on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Seven healthy mongrel dogs were used with a 2-week washout interval between treatments in this study. Anesthesia was induced with propofol and maintained...