An antileishmanial compound, 14-deoxy-11-oxo-andrographolide, a derivative of andrographlide, isolated from the Indian medicinal plant Andrographis paniculata was evaluated for efficacy in free form and in different vesicular delivery modes on hamster model of Leishmaniasis. The subcutaneous injection of free drug reduced the spleen parasite load by 39%, whereas for drug incorporated in liposom...

Keeping aware of the locations of objects while one is moving requires the updating of spatial representations. As long as the objects are visible, attentional tracking is sufficient, but knowing where objects out of view went in relation to one's own body involves an updating of spatial working memory. Here, multiple object tracking was employed to study spatial updating and its neural correla...

efforts to achieve effective and meaningful patient and public involvement (ppi) in healthcare have existed for nearly a century, albeit with limited success. this brief commentary discusses a recent paper by carter and martin exploring the “challenges facing healthwatch, a new consumer champion in england,” and places these challenges in the context of the broader struggle to give a voice to h...

BACKGROUND The need for routine axillary lymph node dissection (ALND) in patients with invasive breast cancer and low-volume sentinel node (SN) involvement is questionable. Accurate prediction of second echelon lymph node involvement could identify those patients most likely to benefit from ALND. METHODS A consecutive series of 317 patients with invasive breast cancer and a tumor positive axi...

Disseminated neonatal herpes simplex virus infection usually presents with multi-organ involvement. Untreated, this disease has a mortality rate of approximately 80%. Here, we describe a well-appearing 3-week old infant with isolated compensated hepatic failure caused by HSV-2.

Erdheim-Chester disease is a non-Langerhans cell histiocytosis that is progressive and may lead on to multi-organ involvement. Pulmonary involvement is rare, its presentation is nonspecific, and it carries an adverse outcome. Several radiological features, when considered together, may point to the diagnosis. This condition should be considered in the differential diagnosis of interstitial lung...

Although Adverse Childhood Experiences (ACEs) are linked to increased health problems and risk behaviors in adulthood, there are no studies on the association between ACEs and adults' states of mind regarding their early childhood attachments, loss, and trauma experiences. To validate the ACEs questions, we analyzed the association between ACEs and emotional support indicators and Adult Attachm...

This study assessed attachment security in adults with high-functioning autism spectrum disorders, using the Adult Attachment Interview (AAI; George, Kaplan, & Main, 1996). Of 20 participants, three were classified as securely attached, the same proportion as would be expected in a general clinical sample. Participants' AAIs were less coherent and lower in reflective function than those of cont...

• An experimental investigation into the impact of Delphi group size and diversity. Focused on surveys that include exchange rationales between rounds. We explored effect opinion diversity panellists’ information (over)load experience process. For sizes up to 19 (whether with diverse opinions or not), we found no evidence overload, de-motivation disengagement. In this paper, investigate members...

Grasp stability during object manipulation is achieved by the grip forces applied normal to the grasped surfaces increasing and decreasing in phase with increases and decreases of destabilizing load forces applied tangential to the grasped surfaces. This force coordination requires that the CNS anticipates the grip forces that match the requirements imposed by the self-generated load forces. He...