Gel electrophoresis of reduced thyroglobulin from normal human thyroids showed five major iodinated components, with estimated molecular masses of >300,000 daltons (14% of thyroglobulin’s iodine), 230,000 (30%), 45,000 (4.5%), 26,000 (17%), and 18,000 (4%). The 26,000and 18,000-dalton components had over 50% of their iodine as thyroxine. The 26,000-dalton iodopeptide had a single NHz-terminal,...

INTRODUCTION Prolonged critically ill patients reveal low circulating thyroid hormone levels without a rise in thyroid stimulating hormone (TSH). This condition is labeled "low 3,5,3'-tri-iodothyronine (T3) syndrome" or "nonthyroidal illness syndrome (NTI)" or "euthyroid sick syndrome". Despite the low circulating and peripheral tissue thyroid hormone levels, thyrotropin releasing hormone (TRH)...

1. The stimulations of DNA-dependent RNA polymerase in isolated rat-liver nuclei by thyroid hormone, human growth hormone and testosterone are compared. 2. Single or multiple administrations of growth-promoting doses of tri-iodo-l-thyronine, human growth hormone and testosterone stimulate the Mg(2+)-activated RNA-polymerase reaction in nuclei from thyroidectomized, hypophysectomized and castrat...

Aim: To evaluate the effect of aqueous extract Hypoestes rosea (AEHR) leaf on thyroid hormones in lead-acetate-induced Albino Rats.
 Study design: Experimental study.
 Place and Duration Study: Department Pharmacology, University Port Harcourt Chemical Pathology, Harcourt, between October, 2019 March, 2020.
 Methodology: A total 140 albino Wistar rats were used for study. The ani...

background: the physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia. objective: the aim of this study was comparison of serum levels of tri?iodothyronine (t3), thyroxine (t4), and thyroid?stimulating hormone (tsh) in preeclampsia and normal pregnancy. materials and methods: in this case?control study, 40 normal pregna...

Activities of phosphatidate phosphohydrolase and palmitoyl-CoA hydrolase were determined in cardiac subcellular fractions prepared from rabbits which had received tri-iodothyronine and from hamsters with hereditary cardiomyopathy (strain BIO 14.6). 1. Both mitochondrial and microsomal fractions of hyperthyroid rabbit hearts produced 4-5 times as much diacylglycerol 3-phosphate from glycerol 3-p...