AIMS Intraoperative radiotherapy (IORT) for locally advanced rectal cancer as an integral part of multimodal treatment, may lead to reduced local recurrence but it is not routinely used. The aim of this paper is to describe our experience with IORT in the treatment of patients with locally advanced adenocarcinoma of the lower third of the rectum. MATERIAL AND METHODS Laparoscopic abdominoperi...

The prognosis in women with locally advanced primary or recurrent gynecologic malignancies is rather poor. Doses of external beam radiation necessary to treat gross or microscopic recurrence among patients surgically treated or previously irradiated exceed what is tolerated by normal structures. In this group of patients, intraoperative radiation therapy (IORT) can be utilized to maximize local...

OBJECT The authors assessed the feasibility of intraoperative radiotherapy (IORT) using a portable radiation source to treat newly diagnosed, surgically resected, solitary brain metastasis (BrM). METHODS In a nonrandomized prospective study, 23 patients with histologically confirmed BrM were treated with an Intrabeam device that delivered 14 Gy to a 2-mm depth to the resection cavity during s...

72 Background: The TARGIT-A trial allowed administration of IORT both pre- and post-pathology. The advantage of post-pathology is the ability to determine eligibility based on margins, pathologic tumor size and nodal status, prior to delivering radiation. However, it is unclear whether having more than one operation before IORT is associated with worse skin toxicity. In this study, we aimed to ...

Aim Patients with locally advanced and recurrent rectal cancer (LARC/LRRC) experience higher rates of local recurrence (LR) poorer overall survival than patients primary restricted to the mesorectum despite improved neoadjuvant treatment regimens radical surgical procedures. Intraoperative radiotherapy (IORT) has been suggested as an adjunctive tool in management these challenging cases. Howeve...

The deadly coronavirus disease (COVID-19) has highlighted the importance of remote health monitoring (RHM). digital twins (DTs) paradigm enables RHM by creating a virtual replica that receives data from physical asset, representing its real-world behavior. However, DTs use passive internet things (IoT) sensors, which limit their potential to specific location or entity. This problem can be addr...

Neoadjuvant therapy including chemotherapy alone or concurrent chemotherapy with external bream radiation is a standard treatment strategy for borderline resectable pancreatic adenocarcinoma and is also used routinely for primary operable cancers at some institutions (1). The use of intraoperative radiation therapy (IORT) has been limited largely because of the logistical issues in delivery of ...

The Internet of Things (IoT) concept is evolving rapidly and influencing new developments in various application domains, such as the Internet of Mobile Things (IoMT), Autonomous Internet of Things (A-IoT), Autonomous System of Things (ASoT), Internet of Autonomous Things (IoAT), Internet of Things Clouds (IoT-C) and the Internet of Robotic Things (IoRT) etc. that are progressing/advancing by u...

background: intraoperative radiation therapy (iort) technique is used to treat a surgically exposed tumor or tumor bed in the treatment of locally advanced intraabdominal, retroperitoneal, pelvic, thoracic, breast and soft tissue tumors. one way to perform iort is to use an existing linac and modify the treatment head using an applicator system. in this study the objectives were to design, and ...

Over one-quarter of a million cases of breast cancer are diagnosed in the United States each year, many of which are early stage.The radiotherapeutic options after breast-conserving surgery in early-stage breast cancer are evolving quickly, with a focus on minimizing treatment volume, toxicity, and treatment duration. One such emerging option is intraoperative radiotherapy (IORT), administered ...