Background Interleukin-1 receptor-associated kinase 4 (IRAK-4) is involved in Toll-Like Receptor (TLR) and (IL-1R) signaling pathways regulating innate immunity. Inhibition of IRAK4 could block the expression cytokines autoimmune disorders such as rheumatoid arthritis. CA-4948 a member oxazolopyridine class inhibitors has been shown to suppress TLR agonist-induced NF-kappaB activation, TNF-alph...