pot experiment was carried out to investigate the effects of ethylenediaminetetraacetic acid (edta) on some morphological characteristics of thlaspi caerulescens l., and also on the accumulation of lead (pb) and zinc (zn) in roots and shoots of t. caerulescens l.. experiments were then set up in three treated pots with doses of 3, 6 and 9 mmol kg-1 of edta and control pots (c: uncontaminated so...

Fe(III) oxides hydrated to various extents are the most abundant iron species in soil. Their extremely low solubility makes them almost unavailable to living organisms. To cope with iron deficiency, many microorganisms synthesize and secrete siderophores [1–5], which are low-molecular-weight compounds that specifically chelate Fe(III) to form stable complexes, into the soil (association constan...

Iron is an important catalyst of oxidative radical reactions and promotes the formation of the hydroxyl radical from the superoxide anion radical and hydrogen peroxide. The stimulatory effect of the hydroxyl radical on lipid peroxidation prompted the speculation that free iron may directly promote inflammation and that iron chelating agents may have useful anti-inflammatory properties. This hyp...

The limitations of current therapies for the treatment of iron overload or radioisotope contamination have stimulated efforts to develop new orally bioavailable iron and actinide chelators. Siderophore-inspired tetradentate, hexadentate and octadentate terephthalamidate and hydroxypyridonate ligands were evaluated in vivo as selective and efficacious iron or actinide chelating agents, with seve...

Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these diseases, it is becoming evident that the next generation of therapies must have multiple functions to combat multiple mechanisms of disease progression. Metal-chelating age...

To prevent side effects of excessive accumulation of iron in the body, chelation therapy is recommended in transfusion-dependent patients. The reaction between deferiprone and iron to form a complex red substance can be described as 3 molecules of the chelator, deferiprone, reacting with a molecule of iron. However, the actual mechanism of the deferiprone-iron binding reaction is not well under...

An expert group of the International Committee on Oral Chelators (ICOC) has recommended a universally effective chelation combination protocol of oral deferiprone (L1) during the day (80-110 mg/kg /day) and subcutaneous deferoxamine (40-60 mg/kg) of a minimum of three nights per week for the rapid, safe and effective depletion of excess body iron in transfused iron loaded patients. Following th...

barium sulfate (barite) is one of the widely used weighting materials in the preparation of drilling fluid for deep oil and gas wells. barite is not soluble in the regular solvents; such as, hydrochloric acid (hcl) and other acids. therefore, in this study, we focused on evaluating the dissolution of the industrial barite particles in different chelating agents. chelating agents; such as, dieth...

a series of 3- hydroxypyridin -4-one derivatives (hpos) as bidentate iron (iii) chelating agents were synthesized from 3- hydroxypyran -4-ones (maltol and ethyl maltol) in three steps through protection of hydroxyl group . the protected compounds were then reacted with suitable primary amines to give benzylated pyridinones . finally, the benzyl group was removed by catalytic hydrogenation to pr...