Myelodysplastic syndromes represent a group of heterogeneous hematopoietic neoplasms derived from an abnormal multipotent progenitor cell, characterized by a hyperproliferative bone marrow, dysplasia of the cellular hemopoietic elements and ineffective erythropoiesis. Anemia is a common finding in myelodysplastic syndrome patients, and blood transfusions are the only therapeutic option in appro...

The Ehrlich ascites tumor takes up intravenous Fe 59 and utilizes much of this for cellular heme formation. In vivo experiments showed tha t the amount of iron utilized by liver and marrow for heme synthesis was directly related to the amount of iron taken up by these tissues. In vitro experiments revealed no difference in iron-protoporphyrin chelation by liver mitochondria from control and tum...

The Ehrlich ascites tumor takes up intravenous Fe 59 and utilizes much of this for cellular heme formation. In vivo experiments showed tha t the amount of iron utilized by liver and marrow for heme synthesis was directly related to the amount of iron taken up by these tissues. In vitro experiments revealed no difference in iron-protoporphyrin chelation by liver mitochondria from control and tum...

Key points Iron acts as a cofactor in the stabilization of hypoxic-inducible factor family, and plays an influential role modulation hypoxic pulmonary vasoconstriction. It is uncertain whether iron regulation altered lowlanders during either (1) ascent to high altitude, or (2) following partial acclimatization, when compared high-altitude adapted Sherpa. During 5050 m, rise artery systolic pres...

Histochemical and MRI studies have demonstrated that MS (multiple sclerosis) patients have abnormal deposition of iron in both gray and white matter structures. Data is emerging indicating that this iron could partake in pathogenesis by various mechanisms, e.g., promoting the production of reactive oxygen species and enhancing the production of proinflammatory cytokines. Iron chelation therapy ...

Mounting evidence suggest that iron overload enhances cancer growth and metastasis; hence, iron chelation is being increasingly used as part of the treatment regimen in patients with cancer. Now whether iron chelation depletes intracellular iron and/or disrupts intracellular iron homeostasis is yet to be fully addressed. MCF-7 and MDA-MB-231 breast cancer cells treated with increasing concentra...

Iron overload remains a concern in MDS patients especially those requiring recurrent blood transfusions. The consequence of iron overload may be more relevant in patients with low and intermediate-1 risk MDS who may survive long enough to experience such manifestations. It is a matter of debate whether this overload has time to yield organ damage, but it is quite evident that cellular damage an...

Background: Metals such as iron, zinc, and copper are critical and necessary for the survival of all living organisms, whereas xenobiotic metals such as lead, cadmium, mercury, and arsenic have no known biologic role. Any metals in high doses can have toxic effects. The aim of this work was to evaluate the hematological changes induced by lead as a toxic metal and characterize the potential eff...

Thalassemia intermedia is a genetically diverse group of diseases that is the result of an imbalance in the production of the alpha and beta chains with ensuing chronic hemolysis, ineffective erythropoiesis, and iron overload. Resulting complications include bone changes, hypercoagulability, and end-organ damage due to iron overload. This decade has witnessed major breakthroughs in the manageme...

BACKGROUND Juvenile hemochromatosis is the most severe form of iron overloading phenotype. Although rare, it should be suspected in patients who present with hypogonadotropic hypogonadism, diabetes mellitus, or cardiomyopathy without a clear cause. CASE PRESENTATION A young Serbian male presenting with end-stage heart failure was referred for extracorporeal membrane oxygenation. An endomyocar...