نتایج جستجو برای: irs 1c

تعداد نتایج: 16581  

2006
V. Srinivas

For many applications (e.g., disaster management, precision farming), it is required to monitor events using multi-date satellite imagery acquired over the same area. This requirement can be best met with a set of satellites whose radiometric characteristics are fully modelled. Even though there is a gamut of satellites with identical or near-identical radiometric characteristics, systematic di...

Journal: :The Journal of biological chemistry 1997
M J Welham H Bone M Levings L Learmonth L M Wang K B Leslie J H Pierce J W Schrader

Insulin receptor substrate 1 (IRS-1), and its structural relative IRS-2, are both phosphorylated on tyrosine following treatment of cells with interleukin-4 (IL-4) and insulin. We have investigated whether both IRS-1 and IRS-2 are expressed in murine lymphohemopoietic cells. T and B lymphocytes and macrophages from primary cultures expressed only IRS-2, which became phosphorylated on tyrosine f...

2000
Stephen F. Previs Dominic J. Withers Jian-Ming Ren Morris F. White Gerald I. Shulman

To examine the impact of homozygous genetic disruption of IRS-1 (IRS-1-/-) or IRS-2 (IRS-2-/-) on basal and insulin stimulated carbohydrate and lipid metabolism in vivo we infused 18-h fasted mice (WT, IRS1-/and IRS2-/-) with [3-3H]glucose and [H5]glycerol and assessed rates of glucose and glycerol turnover under basal (0-90 min) and hyperinsulinemic-euglycemic clamp (90-210 min; 5 mM glucose a...

2016
Benjamin Johns Yemane Yeebiyo Yihdego Lena Kolyada Dereje Dengela Sheleme Chibsa Gunawardena Dissanayake Kristen George Hiwot Solomon Taffese Bradford Lucas

BACKGROUND Indoor residual spraying (IRS) for malaria prevention has traditionally been implemented in Ethiopia by the district health office with technical and operational inputs from regional, zonal, and central health offices. The United States President's Malaria Initiative (PMI) in collaboration with the Government of Ethiopia tested the effectiveness and efficiency of integrating IRS into...

Journal: :Molecular and cellular biology 2006
Zhefu Ma Shannon L Gibson Maura A Byrne Junran Zhang Morris F White Leslie M Shaw

The insulin receptor substrate (IRS) proteins are cytoplasmic adaptors that organize signaling complexes downstream of activated cell surface receptors. Here, we show that IRS-1 and IRS-2, despite significant homology, play critical yet distinct functions in breast cancer, and we identify specific signaling pathways that are influenced by IRS-1 using the polyoma virus middle-T (PyV-MT) transgen...

Journal: :Journal of immunology 2000
D H Schacher R W VanHoy Q Liu S Arkins R Dantzer G G Freund K W Kelley

Insulin receptor substrate-2 (IRS-2) is phosphorylated on tyrosine by a number of cytokine receptors and is implicated in the activation of phosphatidylinositol 3'-kinase (PI3-kinase). Here, we demonstrate that induction of granulocytic differentiation of human promyeloid HL-60 cells leads to an increase in the amount of IRS-2 that is phosphorylated in response to insulin-like growth factor (IG...

Journal: :The Journal of endocrinology 2002
A Shirakami T Toyonaga K Tsuruzoe T Shirotani K Matsumoto K Yoshizato J Kawashima Y Hirashima N Miyamura C R Kahn E Araki

Insulin receptor substrate 1 (IRS-1) gene polymorphisms have been identified in type 2 diabetic patients; however, it is unclear how such polymorphisms contribute to the development of diabetes. Here we introduced obesity in heterozygous IRS-1 knockout (IRS-1(+/-)) mice by gold-thioglucose (GTG) injection and studied the impact of reduced IRS-1 expression on obesity-linked insulin resistance. G...

2017
Chen-Yi Tang Xiao-Fei Man Yue Guo Hao-Neng Tang Jun Tang Ci-La Zhou Shu-Wen Tan Min Wang Hou-De Zhou

Insulin signaling is coordinated by insulin receptor substrates (IRSs). Many insulin responses, especially for blood glucose metabolism, are mediated primarily through Irs-1 and Irs-2. Irs-1 knockout mice show growth retardation and insulin signaling defects, which can be compensated by other IRSs in vivo; however, the underlying mechanism is not clear. Here, we presented an Irs-1 truncated mut...

Journal: :Molecular endocrinology 1998
A M Valverde M Lorenzo S Pons M F White M Benito

In the present study we have investigated the contribution of the insulin receptor substrate proteins (IRS-1 and IRS-2) to the insulin/insulin like growth factor I (IGF-I)-signaling pathways in fetal rat brown adipocytes, a model that expresses both insulin and IGF-I receptors. Insulin/IGF-I rapidly stimulated IRS-1 and IRS-2 tyrosine phosphorylation, their association with p85alpha, and IRS-1-...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2007
J G Simmons Y Ling H Wilkins C R Fuller A J D'Ercole James Fagin P K Lund

Insulin-like growth factor I (IGF-I) potently stimulates intestinal growth. Insulin receptor substrate-1 (IRS-1) mediates proliferative and antiapoptotic actions of IGF-I in cell lines, but its in vivo relevance in intestine is not defined. This study tested the hypothesis that there is cell type-specific dependence on IRS-1 as a mediator of IGF-I action. Length, mass, crypt cell proliferation,...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید