AIMS Better understanding of symptoms of myocardial ischaemia is needed to improve timeliness of treatment for acute coronary syndromes (ACS). Although researchers have suggested sex differences exist in ischaemic symptoms, methodological issues prevent conclusions. Using percutaneous coronary intervention (PCI) balloon inflation as a model of myocardial ischaemia, we explored sex differences i...

Anti-vascular endothelial growth factor (anti-VEGF) therapy has been shown to be effective at improving vision in patients with macular oedema due to diabetic retinopathy and vein occlusions, but blocking VEGF at least in theory could be detrimental to vascular integrity. For this reason, some patients with macular ischaemia were excluded from studies showing the effectiveness of therapy. A con...

OBJECTIVE To review the clinical and experimental methods of detecting intestinal ischaemia and to assess their value in current clinical practice. DATA SOURCES Relevant articles and published reviews on intestinal ischaemia and/or infarction. SUMMARY OF REVIEW The incidence of acute mesenteric ischaemia has increased substantially over the last few decades. Death rates of 70% to 90% have b...

BACKGROUND Different generic quality of life instruments such as the Nottingham Health Profile (NHP) and the Short Form 36 Health Survey (SF-36) have revealed conflicting results in patients with chronic lower limb ischaemia in psychometric attributes in short-term evaluations. The aim of this study was to compare the NHP and the SF-36 regarding internal consistency reliability, validity, respo...

In this issue of the Journal Manfrini et al., demonstrate that radically different autonomic profiles accompany episodes of spontaneous myocardial ischaemia compared to myocardial ischaemia in the same patient. Practicing cardiologists have known for decades that the location of myocardial ischaemia determines the pattern of autonomic response. For example, acute transmural anterior wall myocar...

Low level chemiluminescence of exposed rat intestine was measured during occlusive ischaemia and reperfusion. Spontaneous emission of in vivo rat intestine (10 +/- 1 cps/cm2) decreased almost to zero in animals subjected to ischaemia and when the period of ischaemia lasted only two minutes, chemiluminescence increased beyond control levels (39%, three minutes after reperfusion) at intestine del...

this study investigated the effect of berberine on the hepatic dysfunction and histological damage induced by renal ischaemia/ reperfusion (i/r) at an early stage. there were four groups (n=7). in ber+i/r group, rats received berberine (ber; 15 mg/kg/day) orally for 7 days before induction of ischemia. i/r group received distilled water orally for 7 days. in sham and ber+sham groups in which ar...

OBJECTIVE Intestinal ischaemia following cardiac surgery is a serious complication, which carries a high mortality rate. Several studies have examined pre-operative and intra-operative risk factors. We aimed to develop a multivariate risk model to identify those patients at highest risk of intestinal ischaemia. METHODS Data was prospectively collected for 10,976 consecutive cardiac surgery pa...

Neuroprotective therapy is likely to be most effective in preventing or minimizing the effects of cerebral ischaemia when given as early as possible after the insult. Neuropsychological testing is the gold standard for assessing minor cerebral damage, but is carried out several days or weeks after surgery and is too late to be useful for instituting therapy. Current intraoperative cerebral moni...

The cause of the abnormal resistance to ischaemia of peripheral nerve function in diabetes is unknown. Median nerve function was more resistant to ischaemia in diabetic patients than in control subjects. In diabetic patients the degree of resistance to ischaemia correlated closely with HbAlc but not with the coincident blood glucose level, the duration of diabetes, the vibration perception thre...