Abstract_ Introduction: Viola plant has been used traditionally for the treatment of neurological disorders. We aimed at determining whether pretreatment with Viola spathulata extract can alleviate the severity of ischemic-reperfusion damages and it can exert its protective effects through the regulation of a sodium/calcium exchanger (NCX3) gene expression in a rat brain. Methods: Male Wistar r...

Abstract Brain stroke is an emergency medical condition which occurs mainly due to insufficient blood flow the brain. It results in permanent cellular-level damage. There are two main types of brain stroke, ischemic and hemorrhagic. Ischemic caused by a lack flow, haemorrhagic form internal bleeding. The affected part will not function properly after this attack. Hence, early detection importan...

Excessive poly(ADP-ribose) polymerase-1 (PARP-1) activation plays a significant role in ischemic brain damage. Increasing evidence has supported the hypothesis that PARP-1 induces cell death by depleting intracellular NAD+. Based on our in vitro finding that NAD+ treatment can abolish PARP-1-mediated cell death, we hypothesized that NAD+ administration may decrease ischemic brain injury. In thi...

how to cite this article: eghbalian f, rasuli b, monsef f. frequency, causes, and findings of brain ct scans of neonatal seizure at besat hospital, hamadan, iran. iran j child neurol. 2015 winter;9(1):56-63. abstract objective neonatal seizures are the most common neurological symptoms and often signal an underlying serious neurologic condition. this study determines the frequency of neonatal s...

The ischemia-reperfusion-induced damage in human brain microvascular endothelial cells (BMECs) is associated with disruption of the blood–brain barrier. CXC chemokine ligand 5 (CXCL5) reported to be up-regulated ischemic stroke. However, detailed function CXCL5 this pathological process remains largely unclear. To further analyze stroke, an oxygen–glucose deprivation model on BMECs was construc...

Brain ischemia leading to stroke is a major cause of disability in developed countries. Therapeutic strategies have most commonly focused on protecting neurons from ischemic damage. However, ischemic damage to white matter causes oligodendrocyte death, myelin disruption, and axon dysfunction, and it is partially mediated by glutamate excitotoxicity. We have previously demonstrated that oligoden...

Stroke is one of the leading causes death and disability worldwide. However, treatment options for ischemic stroke remain limited. Matrix-metalloproteinases (MMPs) contribute to brain damage during strokes by disrupting blood-brain barrier (BBB) causing edemas. Carnosine, an endogenous dipeptide, was found us others be protective against injury. In this study, we investigated whether carnosine ...

Objective(s): The alteration of glucose transporters is closely related with the pathogenesis of brain edema. We compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(GLUT-1)-immunoreactive microvessels in their ischemic hippocampal CA1 region. Materials and Methods: Transient cere...

Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils. The extent of ischemic injury was assessed behaviorally by measuring the increases in lo...