OBJECTIVE To evaluate the antidiabetic effect of curcumin and its potential in amelioration of pancreatic islets against damage under diabetic condition. MATERIAL AND METHOD Diabetic mice were induced by injection of STZ (60 mg/kg body weight). Male mice were divided into 3 groups: group I was normal mice, group II was diabetic mice and group III diabetic mice were treated with curcumin (200 ...

The concentration of thyrotropin-releasing hormone (TRH, thyroliberin) in rat islets of Langerhans is 30-fold higher than in whole rat pancreas, indicating that the islets are the main source of pancreatic TRH. The TRH extracted from islets is indistinguishable from synthetic TRH in its immunological and biological properties and in its inactivation by human serum. The physiologic function of i...

Objectives: This study investigates the effects of hydro-alcoholic extract of Prangos ferulacea (L.) Lindle (P.f) on rats' pancreas structure changes and diabetic treatment after streptozotocin injection. Materials and Methods: In this research forty male Wistar rats with body weights of 100±20 gram, were randomly divided into 5 groups with 8 rats per each group. Diabetes was induced in rats b...

Changes in the intracellular concentrations of Ca2 + and cyclic AMP (for reviews see Hedeskov, 1980; Wollheim & Sharp, 1981), as well as alterations in phosphatidylinositol turnover (Freinkel et al., 1975; Clements & Rhoten, 1976; Clements et al., 1977), have been proposed to be key events in stimulus-secretion coupling in the pancreatic fl-cell. The principal mediator of the action of cyclic A...

OBJECTIVES In this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated. MATERIALS AND METHODS Male Wistar rats were divided into control, hyperglycemic, honey treated control, and honey treated hyperglycemic groups. For induction of hyperglycemia, noise str...

The alcoholic extract of Swertia chirayita was tested for its biochemical and pathomorphological effects in streptozotocin induced diabetes rats. Streptozotocin produced effectively all the animals at 45 mg/kg b.w. intraperitonially. diabetic showed significant increase serum levels glucose, cholesterol, triglycerides, ALT AST a reduction insulin levels. treated rats dose 500 b.w with improveme...

The present studies were designed to determine effects of a microgravity model system upon lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-alpha) activity and indexes of insulin and fuel homeostasis of pancreatic islets of Langerhans. Islets (1,726 +/- 117, 150 islet equivalent units) from Wistar-Furth rats were treated as 1) high aspect ratio vessel (HARV) cell culture, 2)...

The editors recently became aware that three images in Figure 4F of this article are duplicated in a 2002 Proceedings of the National Academy of Science of the United States of America (PNAS) publication by this group (1). The specific panels of Figure 4F that were duplicated are the Fas-stained islets cultured in 5.5 mM glucose + IL-1β, the insulin-stained islets cultured in 5.5 mM glucose, an...