introduction: cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. the aim of the present study was to evaluate oxytocin (ot) induced cardioprotection and its signaling pathways on lactate dehydrogenase (ldh) and creatine kinase-mb isoenzyme (ck-mb) in the anesthetized rats. methods: eighty...

Inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase catalyses the phosphorylation of Ins(1,4,5)P(3) to Ins(1,3,4,5)P(4). cDNAs encoding two isoenzymes of Ins(1,4,5)P(3) 3-kinase (3-kinases A and B) have been described previously. In the present study, we report the cloning of a full-length 2052 bp cDNA encoding a third human isoenzyme of the Ins(1,4,5)P(3) 3-kinase family, referred to as iso...

We demonstrate that human placenta is a convenient source of creatine kinase isoenzyme BB. We compare the physicochemical and catalytic properties with those of other creatine kinase isoenzymes: purified human abdominal muscle MM and brain BB. We also describe a stabilizing medium for creatine kinase BB. Human placental and brain BB have similar catalytic properties, the respective Km values fo...

A 49 year old woman presented in June 1998 with left sided pleuritic chest pain, fever, night sweats, flitting arthralgia, and loss of appetite of three weeks’ duration. She also complained of episodic numbness of her fingertips and later her toes and oral ulceration. She was known to have had asthma for the past 24 years and to have had four episodes of arthralgia involving large joints in the...

Perinatal hypoxia is one of the more common complications early adaptation period. This condition defined as a disorder tissue oxygenation during labour and responsible for approximately 23% neonatal mortality. can cause injury failure many organs, including brain, heart kidneys, mainly in mechanism ischaemic-reperfusion injury. Currently, biochemical markers are frequently incorporated diagnos...