introduction: cisplatin is an antineoplastic drug, which is widely used for the treatment of solid tumors. however, its clinical usage is limited because of its side effects such as hepatotoxicity. this study aimed to identify toxic effects of cisplatin on hepatocytes of rats. methods: a total of 45 adult sprague dawley rats weighing 200±30 g were randomly divided into experimental (n=30) and c...

doxorubicin (dox) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. the dose-dependent cardiotoxicity of dox significantly limits its anticancer efficacies. oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to dox mitochondr...

objectives: liver is one of the most sensitive tissues to oxidant damage. hence, the present study was conducted to compare the effects of melissa officinalis (mo) extract and atorvastatin on the activity of liver enzymes in rats. materials and methods: in this experimental study, 60 male wistar rats were selected and allocated to six groups (n=10). the control group received a normal diet, sha...

objective: lamotrigine is an antiepileptic drug, widely used in the treatment of epilepsy; long-term use of this drug can cause hepatotoxicity. zingiber officinale roscoe (ginger) possesses antioxidant properties. in present research, the effect ofhydroalcoholic extract of ginger (heg) on the liver of lamotrigine-treated epileptic rats was investigated material and methods: forty-eight female w...

objective(s):this study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. materials and methods: male wistar rats were anesthetized by thiopental sodium (50 mg/kg, ip) followed by iv injection of heparin (250 iu). remote ischemic preconditioning (ripc) was induce...

1. Colony-stimulating activity appeared in the perfusate of the isolated rat liver during perfusions with either whole rat blood, rat plasma or an artificial perfusate of Eagle's medium and albumin. 2. Dialysable inhibitors of colony formation were also released during perfusions. 3. Colony-stimulating activity in artificial perfusate could be enhanced by the addition of rat plasma in vitro. Co...

High-affinity, limited-capacity nuclear binding activities, putative receptors for triiodothyronine, were detected after incubation of hormone with intact rat pituitary GH1 cells in culture, isolated GH1 cell nuclei, or rat liver nuclei. The total number of triiodothyronine binding sites per nucleus was similar in each case (approximately 8,000). The estimated equilibrium dissociation constants...

background : numerous epidemiologic studies have shown that esophagus cancer is more common in areas with grains containing mycotoxin such as fumonisin b1 (fb1). the aim of this research is to study the effect of long- and short-term of esophagus tissue to fb1 orally administered in animal model. materials and methods : forty-four female mice have been divided in two short- and long-term groups...

THE USE of polyethylene glycol (PEG) in preservation solutions has been associated with a decreased incidence of rejection in clinical and experimental transplantation. Using the isolated perfused rat liver model, we found that PEG, when added to phosphate-buffered sucrose solution (PBSL), provided improved liver preservation. A direct comparison of three different molecular configurations of P...

2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. it appears that tcdd is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. the prominent hepatotoxic effect of tcdd is progressive centrilobular necrosis. the is...