Hemorrhoids are the third most frequent gastrointestinal condition. The symptoms of hemorrhoid illness may include pain, itching, bleeding, soiling, and swelling. This study aimed to examine impact treatment on patients’ quality life. 36 patients with hemorrhoids between 18 60 took part in this longitudinal before after April August 2022. Health-related life (HRQOL) is 0.037<0.051. Lower...

hand eczema is a common distressing skin problem. it is an immune reaction to haptens. thus, substances that inhibit immune system can be effective in the treatment of hand eczema. in this study, topical fumaric acid 5% cream is compared with topical steroid in the treatment of hand eczema. patients with hand eczema were randomly divided into two groups. one group received fumaric acid 5% in a ...

Chronic graft-versus-host disease (GVHD) is a pleotropic syndrome that lacks validated methods of measuring response in clinical trials, although several end points have been proposed. To investigate the prognostic significance of these proposed end points, such as the 2005 National Institutes of Health (NIH) response measures, 2014 NIH response measures, clinician-reported response, and patien...

BACKGROUND Corticosteroids are considered to be particularly effective in reducing nasal congestion and are therefore recommended as first-line treatment in allergic rhinitis patients with moderate to severe and/or persistent symptoms. OBJECTIVE We compared the clinical efficacy of fluticasone propionate aqueous nasal spray (FPANS) 200 microg given once daily, administered in mono-therapy or ...

BACKGROUND Atopic dermatitis (AD) is a chronic allergic inflammatory disease, which manifests itself with eczematous skin lesions. OBJECTIVE We compared the clinical efficacy of tacrolimus ointment (0.1%) given twice a day and oral cyclosporine (3 mg/kg) given once daily. Rescue medication for itching included cetirizine 10-20 mg (equal to one or two tables). METHODS Thirty patients, aged 1...

Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects. Sensory qualities were assessed by questionnaire; intensities and time courses of the "itching" and "burning" sensation were measured alternately, but continuously on a VAS. In addition, axon reflexes were assessed. Only histamine and capsaicin prod...

OBJECTIVES The aim was to develop a clinical outcome assessment (COA) for itching in children with cholestatic pruritus. METHODS This prospective study aimed to enroll patients aged 4-30 years with Alagille syndrome (ALGS) or progressive familial intrahepatic cholestasis type 1 and caregivers of patients aged 5 months to 14 years. Eligible patients experienced itching during ≥3 of the 7 days ...

PURPOSE Nasal cytology is important in the diagnosis and treatment of nasal inflammatory diseases. Treatment of allergic rhinitis (AR) according to nasal cytology has not been fully studied. We plan to explore the individualized treatment of AR according to nasal cytology. METHODS Nasal cytology from 468 AR patients was examined for inflammatory cell quantity (grade 0-5) and the percentage of...